Condition: Vitamin D3 measurement
rs78862524 in
ADAMTS3 gene and
Vitamin D3 measurement
PMID 28757204 2017 Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis.
rs10745742 in
AMDHD1 gene and
Vitamin D3 measurement
PMID 29343764 2018 Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels.
rs55665837 in
COPB1 gene and
Vitamin D3 measurement
PMID 28757204 2017 Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis.
rs10741657 in
CYP2R1 gene and
Vitamin D3 measurement
PMID 29343764 2018 Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels.
PMID 29545823 2018 Genome-Wide Association Study of Serum 25-Hydroxyvitamin D in US Women.
PMID 20418485 2010 Genome-wide association study of circulating vitamin D levels.
PMID 20418485 2010 Suggestive signals for association with 25(OH)D were also observed for SNPs in or near three other genes involved in vitamin D synthesis or activation: rs3829251 on chromosome 11q13.4 in NADSYN1 [encoding nicotinamide adenine dinucleotide (NAD) synthetase; P=8.8x10(-7)], which was in high LD with rs1790349, located in DHCR7, the gene encoding 7-dehydrocholesterol reductase that synthesizes cholesterol from 7-dehydrocholesterol; rs6599638 in the region harboring the open-reading frame 88 (C10orf88) on chromosome 10q26.13 in the vicinity of ACADSB (acyl-Coenzyme A dehydrogenase), involved in cholesterol and vitamin D synthesis (P=3.3x10(-7)); and rs2060793 on chromosome 11p15.2 in CYP2R1 (cytochrome P450, family 2, subfamily R, polypeptide 1, encoding a key C-25 hydroxylase that converts vitamin D3 to an active vitamin D receptor ligand; P=1.4x10(-5)).
rs185378533 in
FLJ42102 gene and
Vitamin D3 measurement
PMID 28757204 2017 Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis.
rs1155563 in
GC gene and
Vitamin D3 measurement
PMID 25208829 2014 Genome-wide association study of vitamin D levels in children: replication in the Western Australian Pregnancy Cohort (Raine) study.
PMID 20418485 2010 Genome-wide association study of circulating vitamin D levels.
PMID 22673963 2012 Genome-wide association analysis of circulating vitamin D levels in children with asthma.
PMID 29343764 2018 Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels.
PMID 29325163 2018 Transethnic Evaluation Identifies Low-Frequency Loci Associated With 25-Hydroxyvitamin D Concentrations.
PMID 28757204 2017 Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis.
PMID 29545823 2018 Genome-Wide Association Study of Serum 25-Hydroxyvitamin D in US Women.
rs2277458 in
GEMIN2;LOC105370459 gene and
Vitamin D3 measurement
PMID 28757204 2017 Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis.
rs3819817 in
HAL gene and
Vitamin D3 measurement
PMID 28757204 2017 Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis.
rs2207173 in
LOC105372568 gene and
Vitamin D3 measurement
PMID 26704534 2016 Genome-wide association study of 25(OH) Vitamin D concentrations in Punjabi Sikhs: Results of the Asian Indian diabetic heart study.
rs10485165 in
LOC105377885 gene and
Vitamin D3 measurement
PMID 17903293 2007 Genome-wide association with select biomarker traits in the Framingham Heart Study.
rs156299 in
LOC107986777 gene and
Vitamin D3 measurement
PMID 25208829 2014 Genome-wide association study of vitamin D levels in children: replication in the Western Australian Pregnancy Cohort (Raine) study.
rs2302190 in
MTMR4 gene and
Vitamin D3 measurement
PMID 25208829 2014 Genome-wide association study of vitamin D levels in children: replication in the Western Australian Pregnancy Cohort (Raine) study.
rs11234027 in
NADSYN1 gene and
Vitamin D3 measurement
PMID 20418485 2010 Genome-wide association study of circulating vitamin D levels.
PMID 29343764 2018 Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels.
PMID 29325163 2018 Transethnic Evaluation Identifies Low-Frequency Loci Associated With 25-Hydroxyvitamin D Concentrations.
PMID 20418485 2010 Suggestive signals for association with 25(OH)D were also observed for SNPs in or near three other genes involved in vitamin D synthesis or activation: rs3829251 on chromosome 11q13.4 in NADSYN1 [encoding nicotinamide adenine dinucleotide (NAD) synthetase; P=8.8x10(-7)], which was in high LD with rs1790349, located in DHCR7, the gene encoding 7-dehydrocholesterol reductase that synthesizes cholesterol from 7-dehydrocholesterol; rs6599638 in the region harboring the open-reading frame 88 (C10orf88) on chromosome 10q26.13 in the vicinity of ACADSB (acyl-Coenzyme A dehydrogenase), involved in cholesterol and vitamin D synthesis (P=3.3x10(-7)); and rs2060793 on chromosome 11p15.2 in CYP2R1 (cytochrome P450, family 2, subfamily R, polypeptide 1, encoding a key C-25 hydroxylase that converts vitamin D3 to an active vitamin D receptor ligand; P=1.4x10(-5)).
PMID 28757204 2017 Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis.
rs13107347 in
NPFFR2 gene and
Vitamin D3 measurement
PMID 29325163 2018 Transethnic Evaluation Identifies Low-Frequency Loci Associated With 25-Hydroxyvitamin D Concentrations.
rs1007392 in
PDE3B gene and
Vitamin D3 measurement
PMID 25208829 2014 Genome-wide association study of vitamin D levels in children: replication in the Western Australian Pregnancy Cohort (Raine) study.
PMID 28757204 2017 Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis.
rs182244780 in
RRAS2 gene and
Vitamin D3 measurement
PMID 28757204 2017 Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis.
rs8018720 in
SEC23A gene and
Vitamin D3 measurement
PMID 29343764 2018 Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels.
rs117865811 in
SPON1 gene and
Vitamin D3 measurement
PMID 28757204 2017 Low-Frequency Synonymous Coding Variation in CYP2R1 Has Large Effects on Vitamin D Levels and Risk of Multiple Sclerosis.