Gene: ADAM10

Alternate names for this Gene: AD10|AD18|CD156c|CDw156|HsT18717|MADM|RAK|kuz

Gene Summary: Members of the ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. This gene encodes and ADAM family member that cleaves many proteins including TNF-alpha and E-cadherin. Alternate splicing results in multiple transcript variants encoding different proteins that may undergo similar processing.

Gene is located in Chromosome: 15

Location in Chromosome : 15q21.3

Description of this Gene: ADAM metallopeptidase domain 10

Type of Gene: protein-coding

rs145518263 in ADAM10 gene and ALZHEIMER DISEASE 18 PMID 24055016 2013 ADAM10 missense mutations potentiate β-amyloid accumulation by impairing prodomain chaperone function.

PMID 19608551 2009 Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity.

rs442495 in ADAM10 gene and Alzheimer's Disease PMID 30617256 2019 Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.

rs4238331 in ADAM10 gene and Body mass index PMID 30108127 2018 A Large Multiethnic Genome-Wide Association Study of Adult Body Mass Index Identifies Novel Loci.

rs483352912 in ADAM10 gene and Reticulate acropigmentation of Kitamura PMID 23666529 2013 Whole-exome sequencing identifies ADAM10 mutations as a cause of reticulate acropigmentation of Kitamura, a clinical entity distinct from Dowling-Degos disease.

rs11638416 in ADAM10 gene and Serum albumin measurement PMID 22286219 2012 Genome-wide association study identifies multiple loci influencing human serum metabolite levels.