Gene: ANKLE1

Alternate names for this Gene: ANKRD41|LEM3|LEMD6

Gene Summary:

Gene is located in Chromosome: 19

Location in Chromosome : 19p13.11

Description of this Gene: ankyrin repeat and LEM domain containing 1

Type of Gene: protein-coding

rs56069439 in ANKLE1 gene and Breast Carcinoma PMID 29059683 2017 Association analysis identifies 65 new breast cancer risk loci.

PMID 27117709 2016 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer.

rs10425939 in ANKLE1 gene and Malignant neoplasm of breast PMID 20852631 2010 A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population.

PMID 20852631 2010 Genotyping these SNPs in 6,800 population-based breast cancer cases and 6,613 controls identified a similar association with estrogen receptor-negative breast cancer (rs2363956 per-allele odds ratio (OR) = 0.83, 95% CI 0.75-0.92, P(trend) = 0.0003) and an association with estrogen receptor-positive disease in the opposite direction (OR = 1.07, 95% CI 1.01-1.14, P(trend) = 0.016).

rs2363956 in ANKLE1 gene and Malignant neoplasm of ovary PMID 20852633 2010 Common variants at 19p13 are associated with susceptibility to ovarian cancer.

rs2363956 in ANKLE1 gene and Triple Negative Breast Neoplasms PMID 24325915 2014 Genome-wide association study identifies 25 known breast cancer susceptibility loci as risk factors for triple-negative breast cancer.

rs2363956 in ANKLE1 gene and ovarian neoplasm PMID 20852633 2010 Common variants at 19p13 are associated with susceptibility to ovarian cancer.