Gene: ARAP2

Alternate names for this Gene: CENTD1|PARX

Gene Summary: The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but it lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. The protein associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics.

Gene is located in Chromosome: 4

Location in Chromosome : 4p14

Description of this Gene: ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2

Type of Gene: protein-coding

rs116105213 in ARAP2 gene and Alzheimer's Disease PMID 29274321 2018 Genome-wide association study of Alzheimer's disease endophenotypes at prediagnosis stages.

rs12651329 in ARAP2 gene and Amyotrophic Lateral Sclerosis PMID 22959728 2013 Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1.

rs1878825 in ARAP2 gene and Diastolic blood pressure PMID 30224653 2018 Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.

rs1397427 in ARAP2 gene and Influenza due to Influenza A virus subtype H1N1 PMID 26379185 2015 No Major Host Genetic Risk Factor Contributed to A(H1N1)2009 Influenza Severity.

rs6834483 in ARAP2 gene and Polysomnography PMID 23251661 2012 Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.