Gene: ARHGAP8

Alternate names for this Gene: BPGAP1|PP610

Gene Summary: This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. GAP proteins alternate between an active (GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. This family member is a multidomain protein that functions to promote Erk activation and cell motility. Alternative splicing results in multiple transcript variants. Read-through transcripts from the upstream proline rich 5, renal (PRR5) gene into this gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene.

Gene is located in Chromosome: 22

Location in Chromosome : 22q13.31

Description of this Gene: Rho GTPase activating protein 8

Type of Gene: protein-coding

Gene: PRR5-ARHGAP8

Alternate names for this Gene: -

Gene Summary: The PRR5-ARHGAP8 mRNA is an infrequent but naturally occurring read-through transcript of the neighboring proline rich 5, renal (PRR5) and Rho GTPase activating protein 8 (ARHGAP8) genes. The resulting fusion protein contains sequence identity with each individual gene product, and it includes domains characteristic of a RhoGAP protein. The significance of this read-through transcript and the function of its protein product have not yet been determined.

Gene is located in Chromosome: 22

Location in Chromosome : 22q13.31

Description of this Gene: PRR5-ARHGAP8 readthrough

Type of Gene: protein-coding