Gene: CSNK2B

Alternate names for this Gene: CK2B|CK2N|CSK2B|Ckb1|Ckb2|G5A|POBINDS

Gene Summary: This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus. Two transcript variants encoding different isoforms have been found for this gene.

Gene is located in Chromosome: 6

Location in Chromosome : 6p21.33

Description of this Gene: casein kinase 2 beta

Type of Gene: protein-coding

Gene: GPANK1

Alternate names for this Gene: ANKRD59|BAT4|D6S54E|G5|GPATCH10

Gene Summary: This gene is located in a cluster of HLA-B-associated transcripts, which is included in the human major histocompatability complex III region. This gene encodes a protein which is thought to play a role in immunity. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Gene is located in Chromosome: 6

Location in Chromosome : 6p21.33

Description of this Gene: G-patch domain and ankyrin repeats 1

Type of Gene: protein-coding

rs3130618 in CSNK2B;GPANK1 gene and Diabetes Mellitus, Insulin-Dependent PMID 17632545 2007 A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene.

rs3130618 in CSNK2B;GPANK1 gene and Epstein-Barr Virus Infections PMID 23326239 2013 A genome-wide integrative genomic study localizes genetic factors influencing antibodies against Epstein-Barr virus nuclear antigen 1 (EBNA-1).

rs3130618 in CSNK2B;GPANK1 gene and Lupus Erythematosus, Systemic PMID 24871463 2014 GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.

rs3130618 in CSNK2B;GPANK1 gene and Mean Corpuscular Volume (result) PMID 23303382 2013 Genome-wide association study of serum albumin:globulin ratio in Korean populations.

rs3130618 in CSNK2B;GPANK1 gene and Membranous glomerulonephritis PMID 21323541 2011 Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy.

rs3130618 in CSNK2B;GPANK1 gene and Myasthenia Gravis PMID 23055271 2012 Risk for myasthenia gravis maps to a (151) Pro→Ala change in TNIP1 and to human leukocyte antigen-B*08.

rs3130618 in CSNK2B;GPANK1 gene and Rheumatoid Arthritis PMID 21156761 2011 A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis.

PMID 17804836 2007 TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study.

PMID 19503088 2009 REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis.