Gene: DSCAML1

Alternate names for this Gene: DSCAM2

Gene Summary: The protein encoded by this gene is a member of the Ig superfamily of cell adhesion molecules and is involved in neuronal differentiation. The encoded membrane-bound protein localizes to the cell surface, where it forms aggregates that repel neuronal processes of the same cell type.

Gene is located in Chromosome: 11

Location in Chromosome : 11q23.3

Description of this Gene: DS cell adhesion molecule like 1

Type of Gene: protein-coding

rs139934868 in DSCAML1 gene and Alzheimer's Disease PMID 29274321 2018 Genome-wide association study of Alzheimer's disease endophenotypes at prediagnosis stages.

rs12787909 in DSCAML1 gene and Lipoprotein (a) measurement PMID 25575512 2015 Evidence for several independent genetic variants affecting lipoprotein (a) cholesterol levels.

rs145556679 in DSCAML1 gene and Triglycerides measurement PMID 28548082 2017 Two novel cardiometabolic associations are at lead variants unique to the founder population sequences: chr16:70790626 (high-density lipoprotein levels beta -1.71 (SE 0.25), P=1.57 × 10<sup>-11</sup>, effect allele frequency (EAF) 0.006); and rs145556679 (triglycerides levels beta -1.13 (SE 0.17), P=2.53 × 10<sup>-11</sup>, EAF 0.013).

PMID 30275531 2018 Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program.

rs145556679 in DSCAML1 gene and VLDL cholesterol measurement PMID 28548082 2017 Whole genome sequencing and imputation in isolated populations identify genetic associations with medically-relevant complex traits.