Gene: HDAC9

Alternate names for this Gene: HD7|HD7b|HD9|HDAC|HDAC7|HDAC7B|HDAC9B|HDAC9FL|HDRP|MITR

Gene Summary: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to the Xenopus and mouse MITR genes. The MITR protein lacks the histone deacetylase catalytic domain. It represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. This encoded protein may play a role in hematopoiesis. Multiple alternatively spliced transcripts have been described for this gene but the full-length nature of some of them has not been determined.

Gene is located in Chromosome: 7

Location in Chromosome : 7p21.1

Description of this Gene: histone deacetylase 9

Type of Gene: protein-coding

rs213273 in HDAC9 gene and ACQUIRED IMMUNODEFICIENCY SYNDROME, PROGRESSION TO PMID 24554482 2014 Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384.

rs213273 in HDAC9 gene and AIDS, PROGRESSION TO PMID 24554482 2014 Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384.

rs117584427 in HDAC9 gene and Alopecia PMID 28196072 2017 Genetic prediction of male pattern baldness.

rs2073963 in HDAC9 gene and Alopecia, Androgenetic, 1 PMID 22693459 2012 Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases.

PMID 29146897 2017 GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk.

PMID 27182965 2016 Detection and interpretation of shared genetic influences on 42 human traits.

rs2073963 in HDAC9 gene and Alopecia, Androgenetic, 2 PMID 22693459 2012 Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases.

PMID 29146897 2017 GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk.

PMID 27182965 2016 Detection and interpretation of shared genetic influences on 42 human traits.

rs2073963 in HDAC9 gene and Alopecia, Androgenetic, 3 PMID 22693459 2012 Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases.

PMID 29146897 2017 GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk.

PMID 27182965 2016 Detection and interpretation of shared genetic influences on 42 human traits.

rs10230371 in HDAC9 gene and Alopecia, Male Pattern PMID 22693459 2012 Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases.

PMID 29146897 2017 GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk.

PMID 27182965 2016 Detection and interpretation of shared genetic influences on 42 human traits.

rs2073963 in HDAC9 gene and Androgenetic Alopecia PMID 22693459 2012 Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases.

PMID 29146897 2017 GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk.

PMID 27182965 2016 Detection and interpretation of shared genetic influences on 42 human traits.

rs61549860 in HDAC9 gene and Bipolar Disorder PMID 26806518 2016 Genetic variants associated with response to lithium treatment in bipolar disorder: a genome-wide association study.

rs1178099 in HDAC9 gene and Body Height PMID 31562340 2019 Characterizing rare and low-frequency height-associated variants in the Japanese population.

PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs17432268 in HDAC9 gene and Brain Waves PMID 29703947 2019 Human brain arousal in the resting state: a genome-wide association study.

rs79524815 in HDAC9 gene and Cerebral Amyloid Angiopathy PMID 29458411 2018 Genome-wide pleiotropy analysis of neuropathological traits related to Alzheimer's disease.

rs11984041 in HDAC9 gene and Cerebrovascular accident PMID 22306652 2012 We identified a new association for large vessel stroke within HDAC9 (encoding histone deacetylase 9) on chromosome 7p21.1 (including further replication in an additional 735 affected individuals and 28,583 controls) (rs11984041; combined P = 1.87 × 10(-11); odds ratio (OR) = 1.42, 95% confidence interval (CI) = 1.28-1.57).

PMID 26089329 2015 Meta-Analysis of Genome-Wide Association Studies Identifies Genetic Risk Factors for Stroke in African Americans.

rs2023938 in HDAC9 gene and Coronary Artery Disease PMID 23202125 2013 Large-scale association analysis identifies new risk loci for coronary artery disease.

rs1178326 in HDAC9 gene and Epilepsy PMID 26220383 2015 GWAS identifies two susceptibility loci for lamotrigine-induced skin rash in patients with epilepsy.

rs540671238 in HDAC9 gene and Fasting blood glucose measurement PMID 31217584 2019 Genetic analyses of diverse populations improves discovery for complex traits.

rs213273 in HDAC9 gene and HIV-1, RESISTANCE TO PMID 24554482 2014 Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384.

rs213273 in HDAC9 gene and HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO PMID 24554482 2014 Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384.

rs11984041 in HDAC9 gene and Ischemic stroke PMID 26708676 2016 Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study.

rs1178121 in HDAC9 gene and Juvenile-Onset Still Disease PMID 27927641 2017 Genetic architecture distinguishes systemic juvenile idiopathic arthritis from other forms of juvenile idiopathic arthritis: clinical and therapeutic implications.

rs1178326 in HDAC9 gene and Maculopapular Lesion PMID 26220383 2015 GWAS identifies two susceptibility loci for lamotrigine-induced skin rash in patients with epilepsy.

rs302147 in HDAC9 gene and Narcolepsy PMID 19629137 2009 Genome-wide association database developed in the Japanese Integrated Database Project.

rs213273 in HDAC9 gene and Neuropathy PMID 24554482 2014 Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384.

rs11764536 in HDAC9 gene and Osteoarthritis of hip PMID 30374069 2018 Meta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritis.

PMID 29559693 2018 Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis.

rs2073963 in HDAC9 gene and Other alopecia PMID 22693459 2012 Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases.

PMID 29146897 2017 GWAS for male-pattern baldness identifies 71 susceptibility loci explaining 38% of the risk.

PMID 27182965 2016 Detection and interpretation of shared genetic influences on 42 human traits.

rs2074633 in HDAC9 gene and Peripheral Arterial Diseases PMID 26488411 2015 Genome-Wide Association Study of Peripheral Arterial Disease in a Japanese Population.

rs76872642 in HDAC9 gene and Reasoning PMID 29907492 2018 Genome-wide association analyses identified loci associated with attention/vigilance (rs830786 within HNF4G), verbal memory (rs67017972 near NDUFS4), and reasoning/problem solving (rs76872642 within HDAC9).

rs1178121 in HDAC9 gene and Rheumatoid Arthritis, Systemic Juvenile PMID 27927641 2017 Genetic architecture distinguishes systemic juvenile idiopathic arthritis from other forms of juvenile idiopathic arthritis: clinical and therapeutic implications.

rs1178121 in HDAC9 gene and Systemic onset juvenile chronic arthritis PMID 27927641 2017 Genetic architecture distinguishes systemic juvenile idiopathic arthritis from other forms of juvenile idiopathic arthritis: clinical and therapeutic implications.

rs1528683 in HDAC9 gene and Vital capacity PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs302153 in HDAC9 gene and White Blood Cell Count procedure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.