Gene: MYRF
Alternate names for this Gene: 11orf9|C11orf9|CUGS|MMERV|MRF|Ndt80|pqn-47
Gene Summary: This gene encodes a transcription factor that is required for central nervous system myelination and may regulate oligodendrocyte differentiation. It is thought to act by increasing the expression of genes that effect myelin production but may also directly promote myelin gene expression. Loss of a similar gene in mouse models results in severe demyelination. Alternative splicing results in multiple transcript variants.
Gene is located in Chromosome: 11
Location in Chromosome : 11q12.2
Description of this Gene: myelin regulatory factor
Type of Gene: protein-coding
Gene: TMEM258
Alternate names for this Gene:
Gene Summary:
Gene is located in Chromosome:
Location in Chromosome :
Description of this Gene:
Type of Gene:
rs174533 in
MYRF;TMEM258 gene and
Adenocarcinoma of large intestine
PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.
rs174533 in
MYRF;TMEM258 gene and
Adenoma of large intestine
PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.
rs174535 in
MYRF;TMEM258 gene and
Adult onset asthma
PMID 30929738 2019 Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct.
rs174535 in
MYRF;TMEM258 gene and
Ankylosing spondylitis
PMID 26974007 2016 Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
rs174535 in
MYRF;TMEM258 gene and
Asthma
PMID 30929738 2019 Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct.
rs174530 in
MYRF;TMEM258 gene and
Blood Protein Measurement
PMID 29403010 2018 Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.
rs174533 in
MYRF;TMEM258 gene and
COLORECTAL CANCER, SUSCEPTIBILITY TO, 1
PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.
rs174533 in
MYRF;TMEM258 gene and
COLORECTAL CANCER, SUSCEPTIBILITY TO, 10
PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.
rs174533 in
MYRF;TMEM258 gene and
COLORECTAL CANCER, SUSCEPTIBILITY TO, 12
PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.
rs174533 in
MYRF;TMEM258 gene and
COLORECTAL CANCER, SUSCEPTIBILITY TO, 3
PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.
rs174535 in
MYRF;TMEM258 gene and
Cholangitis, Sclerosing
PMID 26974007 2016 Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
rs11320420 in
MYRF;TMEM258 gene and
Chronic Kidney Diseases
PMID 29545352 2018 Genome-Wide Association Studies of Metabolites in Patients with CKD Identify Multiple Loci and Illuminate Tubular Transport Mechanisms.
rs174533 in
MYRF;TMEM258 gene and
Colorectal Carcinoma
PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.
rs174533 in
MYRF;TMEM258 gene and
Colorectal Neoplasms
PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.
rs174535 in
MYRF;TMEM258 gene and
Crohn Disease
PMID 26974007 2016 Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
rs174535 in
MYRF;TMEM258 gene and
Fasting blood glucose measurement
PMID 31021400 2019 Pleiotropy informed adaptive association test of multiple traits using genome-wide association study summary data.
rs174535 in
MYRF;TMEM258 gene and
Fatty acid measurement
PMID 25500335 2015 A genome-wide association study of saturated, mono- and polyunsaturated red blood cell fatty acids in the Framingham Heart Offspring Study.
rs61896141 in
MYRF;TMEM258 gene and
Hair Color
PMID 30531825 2018 Genome-wide study of hair colour in UK Biobank explains most of the SNP heritability.
rs174533 in
MYRF;TMEM258 gene and
Hematocrit procedure
PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
rs174533 in
MYRF;TMEM258 gene and
Hemoglobin measurement
PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
rs174529 in
MYRF;TMEM258 gene and
High density lipoprotein measurement
PMID 25961943 2015 The impact of low-frequency and rare variants on lipid levels.
PMID 29507422 2018 A large electronic-health-record-based genome-wide study of serum lipids.
PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
rs174529 in
MYRF;TMEM258 gene and
Iron binding capacity total measurement
PMID 28334935 2017 Genome-wide association study of iron traits and relation to diabetes in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL): potential genomic intersection of iron and glucose regulation?
rs11320420 in
MYRF;TMEM258 gene and
Kidney Failure, Chronic
PMID 29545352 2018 Genome-Wide Association Studies of Metabolites in Patients with CKD Identify Multiple Loci and Illuminate Tubular Transport Mechanisms.
rs174529 in
MYRF;TMEM258 gene and
Low density lipoprotein cholesterol measurement
PMID 31217584 2019 Genetic analyses of diverse populations improves discovery for complex traits.
PMID 29507422 2018 A large electronic-health-record-based genome-wide study of serum lipids.
PMID 31393916 2019 Genetically regulated gene expression underlies lipid traits in Hispanic cohorts.
PMID 28334899 2017 Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels.
PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
rs174533 in
MYRF;TMEM258 gene and
Malignant neoplasm of large intestine
PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.
rs174534 in
MYRF;TMEM258 gene and
Malignant neoplasm of lung
PMID 21725308 2011 A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese.
rs174533 in
MYRF;TMEM258 gene and
Malignant tumor of colon
PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.
rs174535 in
MYRF;TMEM258 gene and
Nasal Polyps
PMID 30643255 2019 A loss-of-function variant in ALOX15 protects against nasal polyps and chronic rhinosinusitis.
rs149803 in
MYRF;TMEM258 gene and
Phospholipid measurement
PMID 21829377 2011 Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium.
rs174535 in
MYRF;TMEM258 gene and
Psoriasis
PMID 26974007 2016 Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.
rs174533 in
MYRF;TMEM258 gene and
Red Blood Cell Count measurement
PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
PMID 29403010 2018 Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.
rs174535 in
MYRF;TMEM258 gene and
Respiratory Tract Diseases
PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
rs174535 in
MYRF;TMEM258 gene and
Serum HDL cholesterol measurement
PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
rs174535 in
MYRF;TMEM258 gene and
Serum LDL cholesterol measurement
PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
rs149803 in
MYRF;TMEM258 gene and
Serum albumin measurement
PMID 22286219 2012 Genome-wide association study identifies multiple loci influencing human serum metabolite levels.
PMID 23281178 2013 A genome-wide assessment of variability in human serum metabolism.
rs174529 in
MYRF;TMEM258 gene and
Serum total cholesterol measurement
PMID 29507422 2018 A large electronic-health-record-based genome-wide study of serum lipids.
PMID 28334899 2017 Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels.
PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
rs174529 in
MYRF;TMEM258 gene and
Total iron binding capacity function
PMID 28334935 2017 Genome-wide association study of iron traits and relation to diabetes in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL): potential genomic intersection of iron and glucose regulation?
rs174529 in
MYRF;TMEM258 gene and
Triglycerides measurement
PMID 25961943 2015 The impact of low-frequency and rare variants on lipid levels.
PMID 31217584 2019 Genetic analyses of diverse populations improves discovery for complex traits.
PMID 29507422 2018 A large electronic-health-record-based genome-wide study of serum lipids.
PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
rs174535 in
MYRF;TMEM258 gene and
Ulcerative Colitis
PMID 26974007 2016 Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci.