Gene: PALB2

Alternate names for this Gene: FANCN|PNCA3

Gene Summary: This gene encodes a protein that may function in tumor suppression. This protein binds to and colocalizes with the breast cancer 2 early onset protein (BRCA2) in nuclear foci and likely permits the stable intranuclear localization and accumulation of BRCA2.

Gene is located in Chromosome: 16

Location in Chromosome : 16p12.2

Description of this Gene: partner and localizer of BRCA2

Type of Gene: protein-coding

rs420259 in PALB2 gene and Bipolar Disorder PMID 17554300 2007 Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.

PMID 21254220 2011 Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder.

rs180177132 in PALB2 gene and Breast Carcinoma PMID 23448497 2013 About 1.5% (95% CI 0.6to 2.4) of Australasian multiple-case breast cancer families attending clinics are segregating protein-truncating mutations in PALB2, most being PALB2 c.3113G>A, p.Trp1038*.

PMID 21285249 2011 Contribution of inherited mutations in the BRCA2-interacting protein PALB2 to familial breast cancer.

PMID 21182766 2010 Further screening for PALB2 c.3113G > A (W1038X) was conducted for 779 families with multiple cases of breast cancer ascertained through family cancer clinics in Australia and New Zealand and 764 population-based controls.

PMID 20122277 2010 A novel germline PALB2 deletion in Polish breast and ovarian cancer patients.

PMID 20412113 2010 PALB2 mutations in European familial pancreatic cancer families.

rs118203998 in PALB2 gene and Hereditary Breast and Ovarian Cancer Syndrome PMID 21365267 2011 PALB2 mutations in familial breast and pancreatic cancer.

PMID 26315354 2015 Germline Mutations in the BRIP1, BARD1, PALB2, and NBN Genes in Women With Ovarian Cancer.

PMID 19609323 2009 Structural basis for recruitment of BRCA2 by PALB2.

PMID 17200671 2007 Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer.

PMID 21409391 2011 BRIP1, PALB2, and RAD51C mutation analysis reveals their relative importance as genetic susceptibility factors for breast cancer.

PMID 21285249 2011 Contribution of inherited mutations in the BRCA2-interacting protein PALB2 to familial breast cancer.

PMID 23448497 2013 Prevalence of PALB2 mutations in Australasian multiple-case breast cancer families.

PMID 21165770 2011 PALB2 mutations in German and Russian patients with bilateral breast cancer.

PMID 26681312 2016 Pathogenic and likely pathogenic variant prevalence among the first 10,000 patients referred for next-generation cancer panel testing.

PMID 19264984 2009 Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene.

PMID 19763884 2010 A PALB2 germline mutation associated with hereditary breast cancer in Italy.

PMID 27783279 2017 Frequency of pathogenic germline mutation in CHEK2, PALB2, MRE11, and RAD50 in patients at high risk for hereditary breast cancer.

PMID 21618343 2011 Germline mutations in the PALB2 gene are population specific and occur with low frequencies in familial breast cancer.

PMID 25099575 2014 Breast-cancer risk in families with mutations in PALB2.

PMID 26898890 2016 Prioritizing Variants in Complete Hereditary Breast and Ovarian Cancer Genes in Patients Lacking Known BRCA Mutations.

PMID 21182766 2010 A PALB2 mutation associated with high risk of breast cancer.

PMID 26534844 2016 Targeted massively parallel sequencing of a panel of putative breast cancer susceptibility genes in a large cohort of multiple-case breast and ovarian cancer families.

PMID 24206657 2013 Hi-Plex for high-throughput mutation screening: application to the breast cancer susceptibility gene PALB2.

PMID 28281021 2017 Multi-gene panel testing for hereditary cancer predisposition in unsolved high-risk breast and ovarian cancer patients.

PMID 27067391 2016 A unified analytic framework for prioritization of non-coding variants of uncertain significance in heritable breast and ovarian cancer.

PMID 24448499 2014 Integrated analysis of germline and somatic variants in ovarian cancer.

PMID 27624329 2016 Haplotype analyses of the c.1027C>T and c.2167_2168delAT recurrent truncating mutations in the breast cancer-predisposing gene PALB2.

PMID 24556926 2014 PALB2 sequencing in Italian familial breast cancer cases reveals a high-risk mutation recurrent in the province of Bergamo.

PMID 24763289 2014 Utilization of multigene panels in hereditary cancer predisposition testing: analysis of more than 2,000 patients.

PMID 23977390 2013 Prevalence of PALB2 mutations in breast cancer patients in multi-ethnic Asian population in Malaysia and Singapore.

PMID 26250988 2015 Protein-truncating variants in moderate-risk breast cancer susceptibility genes: a meta-analysis of high-risk case-control screening studies.

rs1057517602 in PALB2 gene and Malignant neoplasm of breast PMID 27106063 2016 Mutation analysis of the PALB2 gene in unselected pancreatic cancer patients in the Czech Republic.

PMID 24448499 2014 Integrated analysis of germline and somatic variants in ovarian cancer.

PMID 20927582 2011 Mutations in BRCA2 and PALB2 in male breast cancer cases from the United States.

PMID 19584259 2009 PALB2 functionally connects the breast cancer susceptibility proteins BRCA1 and BRCA2.

PMID 19609323 2009 Structural basis for recruitment of BRCA2 by PALB2.

PMID 17200668 2007 PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene.

PMID 25099575 2014 Breast-cancer risk in families with mutations in PALB2.

PMID 17200671 2007 Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer.

PMID 26296701 2015 Exome sequencing reveals frequent deleterious germline variants in cancer susceptibility genes in women with invasive breast cancer undergoing neoadjuvant chemotherapy.

PMID 26283626 2015 Prevalence of PALB2 mutations in Australian familial breast cancer cases and controls.

PMID 26641009 2016 Inherited mutations in cancer susceptibility genes are common among survivors of breast cancer who develop therapy-related leukemia.

PMID 26315354 2015 Germline Mutations in the BRIP1, BARD1, PALB2, and NBN Genes in Women With Ovarian Cancer.

PMID 21365267 2011 PALB2 mutations in familial breast and pancreatic cancer.

PMID 26681312 2016 Pathogenic and likely pathogenic variant prevalence among the first 10,000 patients referred for next-generation cancer panel testing.

PMID 24728327 2014 Germline variation in cancer-susceptibility genes in a healthy, ancestrally diverse cohort: implications for individual genome sequencing.

PMID 24949998 2014 Assessment of PALB2 as a candidate melanoma susceptibility gene.

PMID 24415441 2014 Comprehensive sequencing of PALB2 in patients with breast cancer suggests PALB2 mutations explain a subset of hereditary breast cancer.

PMID 21618343 2011 Germline mutations in the PALB2 gene are population specific and occur with low frequencies in familial breast cancer.

PMID 22241545 2012 Rare germline mutations in PALB2 and breast cancer risk: a population-based study.

PMID 17287723 2007 A recurrent mutation in PALB2 in Finnish cancer families.

PMID 28319063 2017 Our findings establish L35P as the first pathogenic missense mutation in PALB2 and directly demonstrate the requirement of the PALB2-BRCA1 interaction for breast cancer suppression.

PMID 27648926 2017 Whole-exome sequencing and targeted gene sequencing provide insights into the role of PALB2 as a male breast cancer susceptibility gene.

PMID 25575445 2015 Mutation screening of PALB2 in clinically ascertained families from the Breast Cancer Family Registry.

PMID 29922827 2018 Association Between Inherited Germline Mutations in Cancer Predisposition Genes and Risk of Pancreatic Cancer.

PMID 25186627 2015 Frequency of mutations in individuals with breast cancer referred for BRCA1 and BRCA2 testing using next-generation sequencing with a 25-gene panel.

PMID 19423707 2009 PALB2 regulates recombinational repair through chromatin association and oligomerization.

PMID 25452441 2015 Inherited mutations in 17 breast cancer susceptibility genes among a large triple-negative breast cancer cohort unselected for family history of breast cancer.

PMID 16793542 2006 Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2.

PMID 21409391 2011 BRIP1, PALB2, and RAD51C mutation analysis reveals their relative importance as genetic susceptibility factors for breast cancer.

PMID 24206657 2013 Hi-Plex for high-throughput mutation screening: application to the breast cancer susceptibility gene PALB2.

PMID 25525159 2015 RNA splicing. The human splicing code reveals new insights into the genetic determinants of disease.

PMID 21285249 2011 Contribution of inherited mutations in the BRCA2-interacting protein PALB2 to familial breast cancer.

PMID 23448497 2013 Prevalence of PALB2 mutations in Australasian multiple-case breast cancer families.

PMID 18446436 2009 The prevalence of PALB2 germline mutations in BRCA1/BRCA2 negative Chinese women with early onset breast cancer or affected relatives.

PMID 22006311 2011 Mutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencing.

PMID 18302019 2009 Analysis of FANCB and FANCN/PALB2 fanconi anemia genes in BRCA1/2-negative Spanish breast cancer families.

PMID 28724667 2017 Germline Mutations in Cancer Susceptibility Genes in a Large Series of Unselected Breast Cancer Patients.

PMID 20412113 2010 PALB2 mutations in European familial pancreatic cancer families.

PMID 18628482 2008 Penetrance analysis of the PALB2 c.1592delT founder mutation.

PMID 21165770 2011 PALB2 mutations in German and Russian patients with bilateral breast cancer.

PMID 18053174 2007 Identification of a novel truncating PALB2 mutation and analysis of its contribution to early-onset breast cancer in French-Canadian women.

PMID 19863560 2009 The contribution of founder mutations to early-onset breast cancer in French-Canadian women.

PMID 21947752 2012 One c.9004G>A carrier also harbored the PALB2 c.2323C>T (Q775X) mutation found to recur in French Canadian breast cancer cases.

PMID 23302520 2013 We also identified a PALB2 p.Q775X carrier who had papillary serous ovarian cystadenocarcinoma at age 58 among the 238 serous subtype ovarian cancer cases investigated, who also had breast cancer at age 52.

PMID 23341105 2013 Heterozygous mutations in the PALB2 hereditary breast cancer predisposition gene impact on the three-dimensional nuclear organization of patient-derived cell lines.

PMID 26898890 2016 Prioritizing Variants in Complete Hereditary Breast and Ovarian Cancer Genes in Patients Lacking Known BRCA Mutations.

PMID 19264984 2009 Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene.

PMID 26534844 2016 Targeted massively parallel sequencing of a panel of putative breast cancer susceptibility genes in a large cohort of multiple-case breast and ovarian cancer families.

PMID 21182766 2010 Further screening for PALB2 c.3113G > A (W1038X) was conducted for 779 families with multiple cases of breast cancer ascertained through family cancer clinics in Australia and New Zealand and 764 population-based controls.

PMID 23471749 2013 Available data suggests that PALB2 c.3113G>A is a rare mutation with estimated breast cancer risks similar in magnitude to that associated with BRCA2 mutations.

PMID 23934222 2013 Fanconi anemia signaling network regulates the spindle assembly checkpoint.

PMID 20153123 2010 DNA repair alterations in children with pediatric malignancies: novel opportunities to identify patients at risk for high-grade toxicities.

PMID 26976419 2016 Frequency of Germline Mutations in 25 Cancer Susceptibility Genes in a Sequential Series of Patients With Breast Cancer.

PMID 21184274 2011 PALB2 germline mutations in familial breast cancer cases with personal and family history of pancreatic cancer.

PMID 24136930 2013 The PALB2 gene is a strong candidate for clinical testing in BRCA1- and BRCA2-negative hereditary breast cancer.

PMID 26720728 2016 Inherited Mutations in Women With Ovarian Carcinoma.

PMID 23977390 2013 Prevalence of PALB2 mutations in breast cancer patients in multi-ethnic Asian population in Malaysia and Singapore.

PMID 20852946 2010 PALB2: a novel inactivating mutation in a Italian breast cancer family.

PMID 24763289 2014 Utilization of multigene panels in hereditary cancer predisposition testing: analysis of more than 2,000 patients.

PMID 21932393 2012 Novel germline PALB2 truncating mutations in African American breast cancer patients.

PMID 27153395 2016 Evaluation of ACMG-Guideline-Based Variant Classification of Cancer Susceptibility and Non-Cancer-Associated Genes in Families Affected by Breast Cancer.

PMID 25428789 2015 Inherited predisposition to breast cancer among African American women.

PMID 25897114 2015 Local DNA dynamics shape mutational patterns of mononucleotide repeats in human genomes.

PMID 20122277 2010 A novel germline PALB2 deletion in Polish breast and ovarian cancer patients.

PMID 23110154 2012 Mutation analysis of BRCA1, BRCA2, PALB2 and BRD7 in a hospital-based series of German patients with triple-negative breast cancer.

PMID 25980754 2015 Identification of a Variety of Mutations in Cancer Predisposition Genes in Patients With Suspected Lynch Syndrome.

PMID 23824750 2014 Low prevalence of germline PALB2 mutations in Australian triple-negative breast cancer.

PMID 28194609 2017 A high frequency of PALB2 mutations in Jamaican patients with breast cancer.

PMID 28779002 2017 Rare, protein-truncating variants in ATM, CHEK2 and PALB2, but not XRCC2, are associated with increased breast cancer risks.

PMID 24556926 2014 PALB2 sequencing in Italian familial breast cancer cases reveals a high-risk mutation recurrent in the province of Bergamo.

PMID 24998779 2014 PALB2: the hub of a network of tumor suppressors involved in DNA damage responses.

PMID 25225577 2014 Mutation analysis of PALB2 in BRCA1 and BRCA2-negative breast and/or ovarian cancer families from Eastern Ontario, Canada.

PMID 26786923 2016 Panel Testing for Familial Breast Cancer: Calibrating the Tension Between Research and Clinical Care.

PMID 24556621 2014 Frequent germline deleterious mutations in DNA repair genes in familial prostate cancer cases are associated with advanced disease.

PMID 25356972 2015 BRCA1, BRCA2, PALB2, and CDKN2A mutations in familial pancreatic cancer: a PACGENE study.

PMID 26270727 2015 Clinical Actionability of Multigene Panel Testing for Hereditary Breast and Ovarian Cancer Risk Assessment.

PMID 26689913 2015 Patterns and functional implications of rare germline variants across 12 cancer types.

PMID 27631815 2017 Frequency of germline PALB2 mutations among women with epithelial ovarian cancer.

PMID 27433846 2016 Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer.

PMID 26757417 2016 Identification of germline alterations in breast cancer predisposition genes among Malaysian breast cancer patients using panel testing.

PMID 25794774 2015 Prevalence of PALB2 mutations in the Creighton University Breast Cancer Family Registry.

PMID 29263802 2016 Inherited breast cancer predisposition in Asians: multigene panel testing outcomes from Singapore.

PMID 25337758 2014 Breast-cancer risk in families with mutations in PALB2.

PMID 26911350 2016 Detection of high frequency of mutations in a breast and/or ovarian cancer cohort: implications of embracing a multi-gene panel in molecular diagnosis in India.

PMID 28678401 2017 Assessing the spectrum of germline variation in Fanconi anemia genes among patients with head and neck carcinoma before age 50.

rs118203997 in PALB2 gene and Neoplastic Syndromes, Hereditary PMID 25525159 2015 RNA splicing. The human splicing code reveals new insights into the genetic determinants of disease.

PMID 21285249 2011 Contribution of inherited mutations in the BRCA2-interacting protein PALB2 to familial breast cancer.

PMID 17200672 2007 Fanconi anemia is associated with a defect in the BRCA2 partner PALB2.

PMID 23935836 2013 Analysis of PALB2 gene in BRCA1/BRCA2 negative Spanish hereditary breast/ovarian cancer families with pancreatic cancer cases.

PMID 17200671 2007 Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer.

PMID 24728327 2014 Germline variation in cancer-susceptibility genes in a healthy, ancestrally diverse cohort: implications for individual genome sequencing.

PMID 27356891 2016 Undefined familial colorectal cancer and the role of pleiotropism in cancer susceptibility genes.

PMID 26845104 2016 Improving performance of multigene panels for genomic analysis of cancer predisposition.

PMID 28008555 2017 Male breast cancer in a multi-gene panel testing cohort: insights and unexpected results.

PMID 26898890 2016 Prioritizing Variants in Complete Hereditary Breast and Ovarian Cancer Genes in Patients Lacking Known BRCA Mutations.

PMID 21165770 2011 PALB2 mutations in German and Russian patients with bilateral breast cancer.

PMID 26681312 2016 Pathogenic and likely pathogenic variant prevalence among the first 10,000 patients referred for next-generation cancer panel testing.

PMID 22241545 2012 Rare germline mutations in PALB2 and breast cancer risk: a population-based study.

PMID 21365267 2011 PALB2 mutations in familial breast and pancreatic cancer.

PMID 17200668 2007 PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene.

PMID 26641009 2016 Inherited mutations in cancer susceptibility genes are common among survivors of breast cancer who develop therapy-related leukemia.

PMID 26283626 2015 Prevalence of PALB2 mutations in Australian familial breast cancer cases and controls.

PMID 21618343 2011 Germline mutations in the PALB2 gene are population specific and occur with low frequencies in familial breast cancer.

PMID 24870022 2014 Exploring the roles of PALB2 at the crossroads of DNA repair and cancer.

PMID 25099575 2014 Breast-cancer risk in families with mutations in PALB2.

PMID 23334666 2013 The genetic landscape of high-risk neuroblastoma.

PMID 26564480 2015 Mutation analysis of PALB2 gene in French breast cancer families.

PMID 24136930 2013 The PALB2 gene is a strong candidate for clinical testing in BRCA1- and BRCA2-negative hereditary breast cancer.

PMID 23448497 2013 Prevalence of PALB2 mutations in Australasian multiple-case breast cancer families.

PMID 21409391 2011 BRIP1, PALB2, and RAD51C mutation analysis reveals their relative importance as genetic susceptibility factors for breast cancer.

PMID 19264984 2009 Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene.

PMID 18446436 2009 The prevalence of PALB2 germline mutations in BRCA1/BRCA2 negative Chinese women with early onset breast cancer or affected relatives.

PMID 22006311 2011 Mutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencing.

PMID 23977390 2013 Prevalence of PALB2 mutations in breast cancer patients in multi-ethnic Asian population in Malaysia and Singapore.

PMID 17420451 2007 Analysis of PALB2/FANCN-associated breast cancer families.

PMID 25186627 2015 Frequency of mutations in individuals with breast cancer referred for BRCA1 and BRCA2 testing using next-generation sequencing with a 25-gene panel.

PMID 23935381 2013 PALB2 and breast cancer: ready for clinical translation!

PMID 24556926 2014 PALB2 sequencing in Italian familial breast cancer cases reveals a high-risk mutation recurrent in the province of Bergamo.

PMID 27624329 2016 Haplotype analyses of the c.1027C>T and c.2167_2168delAT recurrent truncating mutations in the breast cancer-predisposing gene PALB2.

PMID 21184274 2011 PALB2 germline mutations in familial breast cancer cases with personal and family history of pancreatic cancer.

PMID 19763884 2010 A PALB2 germline mutation associated with hereditary breast cancer in Italy.

PMID 18302019 2009 Analysis of FANCB and FANCN/PALB2 fanconi anemia genes in BRCA1/2-negative Spanish breast cancer families.

PMID 26720728 2016 Inherited Mutations in Women With Ovarian Carcinoma.

PMID 28724667 2017 Germline Mutations in Cancer Susceptibility Genes in a Large Series of Unselected Breast Cancer Patients.

PMID 27553368 2016 Implementation of next-generation sequencing for molecular diagnosis of hereditary breast and ovarian cancer highlights its genetic heterogeneity.

PMID 25337756 2014 Breast-cancer risk in families with mutations in PALB2.

PMID 28024868 2017 Germline Mutations in PALB2, BRCA1, and RAD51C, Which Regulate DNA Recombination Repair, in Patients With Gastric Cancer.

PMID 20412113 2010 PALB2 mutations in European familial pancreatic cancer families.

PMID 24448499 2014 Integrated analysis of germline and somatic variants in ovarian cancer.

PMID 23941127 2013 Evaluation of the need for routine clinical testing of PALB2 c.1592delT mutation in BRCA negative Northern Finnish breast cancer families.

PMID 19383810 2009 The breast cancer susceptibility mutation PALB2 1592delT is associated with an aggressive tumor phenotype.

PMID 25452441 2015 Inherited mutations in 17 breast cancer susceptibility genes among a large triple-negative breast cancer cohort unselected for family history of breast cancer.

PMID 17287723 2007 A recurrent mutation in PALB2 in Finnish cancer families.

PMID 18628482 2008 Penetrance analysis of the PALB2 c.1592delT founder mutation.

PMID 24763289 2014 Utilization of multigene panels in hereditary cancer predisposition testing: analysis of more than 2,000 patients.

PMID 24415441 2014 Comprehensive sequencing of PALB2 in patients with breast cancer suggests PALB2 mutations explain a subset of hereditary breast cancer.

PMID 27783279 2017 Frequency of pathogenic germline mutation in CHEK2, PALB2, MRE11, and RAD50 in patients at high risk for hereditary breast cancer.

PMID 27798748 2017 Revisiting breast cancer patients who previously tested negative for BRCA mutations using a 12-gene panel.

PMID 23341105 2013 Heterozygous mutations in the PALB2 hereditary breast cancer predisposition gene impact on the three-dimensional nuclear organization of patient-derived cell lines.

PMID 23302520 2013 Contribution of the PALB2 c.2323C>T [p.Q775X] founder mutation in well-defined breast and/or ovarian cancer families and unselected ovarian cancer cases of French Canadian descent.

PMID 18053174 2007 Identification of a novel truncating PALB2 mutation and analysis of its contribution to early-onset breast cancer in French-Canadian women.

PMID 26489409 2015 PALB2 mutations in breast cancer patients from a multi-ethnic region in northwest China.

PMID 22692731 2012 Germline mutations in BRIP1 and PALB2 in Jewish high cancer risk families.

PMID 24141787 2014 Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair.

PMID 28240985 2017 A PALB2-interacting domain in RNF168 couples homologous recombination to DNA break-induced chromatin ubiquitylation.

PMID 20871615 2010 Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination.

PMID 28779002 2017 Rare, protein-truncating variants in ATM, CHEK2 and PALB2, but not XRCC2, are associated with increased breast cancer risks.

PMID 28158555 2017 Cancer-causing mutations in the tumor suppressor PALB2 reveal a novel cancer mechanism using a hidden nuclear export signal in the WD40 repeat motif.

PMID 27433846 2016 Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer.

PMID 27595995 2016 PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS.

PMID 25575445 2015 Mutation screening of PALB2 in clinically ascertained families from the Breast Cancer Family Registry.

PMID 25225577 2014 Mutation analysis of PALB2 in BRCA1 and BRCA2-negative breast and/or ovarian cancer families from Eastern Ontario, Canada.

PMID 21182766 2010 A PALB2 mutation associated with high risk of breast cancer.

PMID 25356972 2015 BRCA1, BRCA2, PALB2, and CDKN2A mutations in familial pancreatic cancer: a PACGENE study.

PMID 23471749 2013 The incidence of PALB2 c.3113G>A in women with a strong family history of breast and ovarian cancer attending familial cancer centres in Australia.

PMID 25959805 2015 Clinical outcomes in women with breast cancer and a PALB2 mutation: a prospective cohort analysis.

PMID 22310028 2012 Rare occurrence of PALB2 mutations in ovarian cancer patients from the Volga-Ural region.

PMID 28279176 2017 PALB2 mutations in BRCA1/2-mutation negative breast and ovarian cancer patients from Poland.

PMID 24240112 2014 Germline and somatic mutations in homologous recombination genes predict platinum response and survival in ovarian, fallopian tube, and peritoneal carcinomas.

PMID 20852946 2010 PALB2: a novel inactivating mutation in a Italian breast cancer family.

PMID 25619955 2015 Candidate gene analysis of BRCA1/2 mutation-negative high-risk Russian breast cancer patients.

PMID 25428789 2015 Inherited predisposition to breast cancer among African American women.

PMID 23112754 2012 Shared Copy Number Variation in Simultaneous Nephroblastoma and Neuroblastoma due to Fanconi Anemia.

PMID 21932393 2012 Novel germline PALB2 truncating mutations in African American breast cancer patients.

PMID 24549055 2014 Next-generation sequencing for the diagnosis of hereditary breast and ovarian cancer using genomic capture targeting multiple candidate genes.

PMID 28454591 2017 Lost in translation: returning germline genetic results in genome-scale cancer research.

PMID 27099641 2016 PALB2: research reaching to clinical outcomes for women with breast cancer.

PMID 24061862 2014 Prevalence of PALB2 mutation c.509_510delGA in unselected breast cancer patients from Central and Eastern Europe.

PMID 25330149 2015 Mutations predisposing to breast cancer in 12 candidate genes in breast cancer patients from Poland.

PMID 26270727 2015 Clinical Actionability of Multigene Panel Testing for Hereditary Breast and Ovarian Cancer Risk Assessment.

PMID 20582465 2011 PALB2 analysis in BRCA2-like families.

PMID 20122277 2010 A novel germline PALB2 deletion in Polish breast and ovarian cancer patients.

PMID 23110154 2012 Mutation analysis of BRCA1, BRCA2, PALB2 and BRD7 in a hospital-based series of German patients with triple-negative breast cancer.

PMID 25980754 2015 Identification of a Variety of Mutations in Cancer Predisposition Genes in Patients With Suspected Lynch Syndrome.

PMID 28194609 2017 A high frequency of PALB2 mutations in Jamaican patients with breast cancer.

PMID 23824750 2014 Low prevalence of germline PALB2 mutations in Australian triple-negative breast cancer.

PMID 27469594 2016 A Survey of BRCA1, BRCA2, and PALB2 mutations in women with breast cancer in Trinidad and Tobago.

PMID 28453507 2017 Genetic Cancer Risk Assessment for Breast Cancer in Latin America.

PMID 19609323 2009 Structural basis for recruitment of BRCA2 by PALB2.

PMID 28709830 2017 Pathologic findings in breast, fallopian tube, and ovary specimens in non-BRCA hereditary breast and/or ovarian cancer syndromes: a study of 18 patients with deleterious germline mutations in RAD51C, BARD1, BRIP1, PALB2, MUTYH, or CHEK2.

PMID 24556621 2014 Frequent germline deleterious mutations in DNA repair genes in familial prostate cancer cases are associated with advanced disease.

PMID 26315354 2015 Germline Mutations in the BRIP1, BARD1, PALB2, and NBN Genes in Women With Ovarian Cancer.

PMID 23561644 2013 Exome sequencing identifies nonsegregating nonsense ATM and PALB2 variants in familial pancreatic cancer.

PMID 28152038 2017 Exome sequencing covers >98% of mutations identified on targeted next generation sequencing panels.

PMID 26976419 2016 Frequency of Germline Mutations in 25 Cancer Susceptibility Genes in a Sequential Series of Patients With Breast Cancer.

PMID 27631815 2017 Frequency of germline PALB2 mutations among women with epithelial ovarian cancer.

PMID 25794774 2015 Prevalence of PALB2 mutations in the Creighton University Breast Cancer Family Registry.

PMID 26757417 2016 Identification of germline alterations in breast cancer predisposition genes among Malaysian breast cancer patients using panel testing.

PMID 28825143 2017 Germline mutations of PALB2 gene in a sequential series of Chinese patients with breast cancer.

PMID 26556299 2016 Germline Variants in Targeted Tumor Sequencing Using Matched Normal DNA.

PMID 25337758 2014 Breast-cancer risk in families with mutations in PALB2.

PMID 26534844 2016 Targeted massively parallel sequencing of a panel of putative breast cancer susceptibility genes in a large cohort of multiple-case breast and ovarian cancer families.

PMID 25666743 2015 Analysis of PALB2 in a cohort of Italian breast cancer patients: identification of a novel PALB2 truncating mutation.

PMID 27878467 2017 Outcomes of retesting BRCA negative patients using multigene panels.

PMID 26023681 2015 Use of Whole Genome Sequencing for Diagnosis and Discovery in the Cancer Genetics Clinic.