Gene: PTPRG

Alternate names for this Gene: HPTPG|PTPG|R-PTP-GAMMA|RPTPG

Gene Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene.

Gene is located in Chromosome: 3

Location in Chromosome : 3p14.2

Description of this Gene: protein tyrosine phosphatase receptor type G

Type of Gene: protein-coding

rs7609954 in PTPRG gene and Alzheimer's Disease PMID 26830138 2016 Using a multivariate phenotype combining affection status and onset age, meta-analysis of the association results revealed three single nucleotide polymorphisms (SNPs) that achieved genome-wide significance for association with AD risk: rs7609954 in the gene PTPRG (P-value=3.98 × 10<sup>-8</sup>), rs1347297 in the gene OSBPL6 (P-value=4.53 × 10<sup>-8</sup>), and rs1513625 near PDCL3 (P-value=4.28 × 10<sup>-8</sup>).

rs13061878 in PTPRG gene and Attention deficit hyperactivity disorder PMID 27890468 2017 Genetic Overlap Between Attention-Deficit/Hyperactivity Disorder and Bipolar Disorder: Evidence From Genome-wide Association Study Meta-analysis.

rs7633054 in PTPRG gene and Bacteremia PMID 27236921 2016 Polymorphism in a lincRNA Associates with a Doubled Risk of Pneumococcal Bacteremia in Kenyan Children.

rs13061878 in PTPRG gene and Bipolar Disorder PMID 27890468 2017 Genetic Overlap Between Attention-Deficit/Hyperactivity Disorder and Bipolar Disorder: Evidence From Genome-wide Association Study Meta-analysis.

rs73096591 in PTPRG gene and Body Height PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs1911746 in PTPRG gene and Body mass index PMID 30239722 2019 Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.

PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs704341 in PTPRG gene and Cerebrovascular accident PMID 26089329 2015 Meta-Analysis of Genome-Wide Association Studies Identifies Genetic Risk Factors for Stroke in African Americans.

rs10490775 in PTPRG gene and Fuchs Endothelial Dystrophy PMID 20825314 2010 E2-2 protein and Fuchs's corneal dystrophy.

rs704341 in PTPRG gene and Ischemic stroke PMID 26089329 2015 Meta-Analysis of Genome-Wide Association Studies Identifies Genetic Risk Factors for Stroke in African Americans.

rs13082242 in PTPRG gene and Leukemia, Myelocytic, Acute PMID 27903959 2017 Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.

rs17065527 in PTPRG gene and Mean blood pressure PMID 22510845 2012 Pathway-based genome-wide association analysis of coronary heart disease identifies biologically important gene sets.

rs652889 in PTPRG gene and QT interval feature (observable entity) PMID 20031603 2009 A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project.

rs1713534 in PTPRG gene and Serum albumin measurement PMID 23281178 2013 A genome-wide assessment of variability in human serum metabolism.

rs7621604 in PTPRG gene and Waist-Hip Ratio PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.