Gene: SPC25

Alternate names for this Gene: AD024|SPBC25|hSpc25

Gene Summary: This gene encodes a protein that may be involved in kinetochore-microtubule interaction and spindle checkpoint activity.

Gene is located in Chromosome: 2

Location in Chromosome : 2q24.3

Description of this Gene: SPC25 component of NDC80 kinetochore complex

Type of Gene: protein-coding

Gene: G6PC2

Alternate names for this Gene: IGRP

Gene Summary: This gene encodes an enzyme belonging to the glucose-6-phosphatase catalytic subunit family. These enzymes are part of a multicomponent integral membrane system that catalyzes the hydrolysis of glucose-6-phosphate, the terminal step in gluconeogenic and glycogenolytic pathways, allowing the release of glucose into the bloodstream. The family member encoded by this gene is found in pancreatic islets and does not exhibit phosphohydrolase activity, but it is a major target of cell-mediated autoimmunity in diabetes. Several alternatively spliced transcript variants of this gene have been described, but their biological validity has not been determined.

Gene is located in Chromosome: 2

Location in Chromosome : 2q31.1

Description of this Gene: glucose-6-phosphatase catalytic subunit 2

Type of Gene: protein-coding

rs560887 in SPC25;G6PC2 gene and Amino acids measurement PMID 27005778 2016 Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA.

rs560887 in SPC25;G6PC2 gene and Birth Weight PMID 31043758 2019 Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors.

rs560887 in SPC25;G6PC2 gene and Body mass index PMID 22581228 2012 A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.

rs560887 in SPC25;G6PC2 gene and Calcification of coronary artery PMID 22916037 2012 Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.

rs2232326 in SPC25;G6PC2 gene and Fasting blood glucose measurement PMID 29621232 2018 Identification and functional analysis of glycemic trait loci in the China Health and Nutrition Survey.

PMID 25625282 2015 Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus.

PMID 23903356 2013 Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies.

PMID 20081858 2010 New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.

PMID 25631608 2015 Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility.

PMID 19060907 2009 Variants in MTNR1B influence fasting glucose levels.

PMID 28270201 2017 Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants.

PMID 18451265 2008 A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels.

PMID 22885924 2012 Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.

PMID 22581228 2012 A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.

PMID 31217584 2019 Genetic analyses of diverse populations improves discovery for complex traits.

rs560887 in SPC25;G6PC2 gene and Fasting blood sugar result PMID 22885924 2012 Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.

rs2232326 in SPC25;G6PC2 gene and Glucose measurement PMID 29403010 2018 Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.

PMID 19060910 2009 Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.

rs560887 in SPC25;G6PC2 gene and Metabolic Syndrome X PMID 22399527 2012 Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.

rs560887 in SPC25;G6PC2 gene and Protein measurement PMID 27005778 2016 Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA.

rs560887 in SPC25;G6PC2 gene and Serum albumin measurement PMID 22286219 2012 Genome-wide association study identifies multiple loci influencing human serum metabolite levels.

rs2232326 in SPC25;G6PC2 gene and elevated blood glucose level PMID 29403010 2018 Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.

PMID 19060910 2009 Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.