Gene: THSD7A

Alternate names for this Gene: -

Gene Summary: The protein encoded by this gene is found almost exclusively in endothelial cells from placenta and umbilical cord. The encoded protein appears to interact with alpha(V)beta(3) integrin and paxillin to inhibit endothelial cell migration and tube formation. This protein may be involved in cytoskeletal organization. Variations in this gene may be associated with low bone mineral density in osteoporosis.

Gene is located in Chromosome: 7

Location in Chromosome : 7p21.3

Description of this Gene: thrombospondin type 1 domain containing 7A

Type of Gene: protein-coding

rs113779084 in THSD7A gene and Bipolar Disorder PMID 31043756 2019 Genome-wide association study identifies 30 loci associated with bipolar disorder.

rs13247707 in THSD7A gene and Brain Waves PMID 29703947 2019 Human brain arousal in the resting state: a genome-wide association study.

rs17165136 in THSD7A gene and Coronary Artery Disease PMID 29472232 2018 We performed genome-wide screening followed by multicenter validation in 8 cohorts consisting of 21 828 participants of Han ethnicity and identified 3 novel intragenic SNPs (single nucleotide polymorphisms), rs9486729 (<i>SCML4</i> [Scm polycomb group protein-like 4]; odds ratio, 1.25; 95% CI, 1.17-1.34; <i>P</i>=3.51×10<sup>-11</sup>), rs17165136 (<i>THSD7A</i> [thrombospondin type 1 domain-containing 7A]; odds ratio 1.28; 95% CI, 1.21-1.35; <i>P</i><1.00×10<sup>-25</sup>), and rs852787 (<i>DAB1</i> [disabled-1]; odds ratio, 1.29; 95% CI, 1.21-1.38; <i>P</i>=2.02×10<sup>-14</sup>), associated with CAD with genome-wide significance.

rs1635183 in THSD7A gene and Forced expiratory volume function PMID 26423011 2015 Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank.

rs12699251 in THSD7A gene and Glaucoma PMID 30054594 2018 Genome-wide association study of intraocular pressure uncovers new pathways to glaucoma.

rs2526101 in THSD7A gene and Glaucoma, Open-Angle PMID 29891935 2018 A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci.

rs118134876 in THSD7A gene and Intelligence PMID 29844566 2018 Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.

rs1635181 in THSD7A gene and Leukemia, Myelocytic, Acute PMID 27903959 2017 Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.

rs1635182 in THSD7A gene and Tonometry PMID 29785010 2018 Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma.

rs118134876 in THSD7A gene and mathematical ability PMID 30038396 2018 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.

rs10260419 in THSD7A gene and ovarian neoplasm PMID 30898391 2019 Genome-wide association studies identify susceptibility loci for epithelial ovarian cancer in east Asian women.