Gene: TREM2

Alternate names for this Gene: PLOSL2|TREM-2|Trem2a|Trem2b|Trem2c

Gene Summary: This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene is located in Chromosome: 6

Location in Chromosome : 6p21.1

Description of this Gene: triggering receptor expressed on myeloid cells 2

Type of Gene: protein-coding

Gene: LOC105375056

Alternate names for this Gene:

Gene Summary:

Gene is located in Chromosome:

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rs143332484 in TREM2;LOC105375056 gene and Alzheimer's Disease PMID 30617256 2019 Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.

rs121908402 in TREM2;LOC105375056 gene and POLYCYSTIC LIPOMEMBRANOUS OSTEODYSPLASIA WITH SCLEROSING LEUKOENCEPHALOPATHY PMID 15883308 2005 The genetic causes of basal ganglia calcification, dementia, and bone cysts: DAP12 and TREM2.

PMID 18546367 2008 Mutations in TREM2 lead to pure early-onset dementia without bone cysts.

rs104894001 in TREM2;LOC105375056 gene and POLYCYSTIC LIPOMEMBRANOUS OSTEODYSPLASIA WITH SCLEROSING LEUKOENCEPHALOPATHY 2 PMID 12080485 2002 Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype.

PMID 15883308 2005 The genetic causes of basal ganglia calcification, dementia, and bone cysts: DAP12 and TREM2.

PMID 12754369 2003 An Italian family affected by Nasu-Hakola disease with a novel genetic mutation in the TREM2 gene.

PMID 29142083 2017 Evidence of CNS β-amyloid deposition in Nasu-Hakola disease due to the TREM2 Q33X mutation.

PMID 28768830 2017 Neurodegeneration-associated mutant TREM2 proteins abortively cycle between the ER and ER-Golgi intermediate compartment.

PMID 27995897 2016 Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms.

PMID 12925681 2003 DAP12/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic features.

PMID 23399524 2013 Polycystic Lipomembranous Osteodysplasia with Sclerosing Leukoencephalopathy (PLOSL): a new report of an Italian woman and review of the literature.

PMID 25615530 2015 Disease-Associated Mutations of TREM2 Alter the Processing of N-Linked Oligosaccharides in the Golgi Apparatus.