Gene: TUBGCP4
Alternate names for this Gene: 76P|GCP-4|GCP4|Grip76|MCCRP3
Gene Summary: This gene encodes a component of the gamma-tubulin ring complex, which is required for microtubule nucleation. In mammalian cells, the protein localizes to centrosomes in association with gamma-tubulin. Crystal structure analysis revealed a structure composed of five helical bundles arranged around conserved hydrophobic cores. An exposed surface area located in the C-terminal domain is essential and sufficient for direct binding to gamma-tubulin. Mutations in this gene that alter microtubule organization are associated with microcephaly and chorioretinopathy. Alternative splicing results in multiple transcript variants.
Gene is located in Chromosome: 15
Location in Chromosome : 15q15.3
Description of this Gene: tubulin gamma complex associated protein 4
Type of Gene: protein-coding