Variant: rs11540652 

    present in Gene: TP53
    present in Chromosome: 17
    Position on Chromosome: 7674220
    Alleles of this Variant: C/A;G;T

rs11540652 in TP53 gene and Adenocarcinoma of lung (disorder) PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs11540652 in TP53 gene and Adenocarcinoma of pancreas PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs11540652 in TP53 gene and Adenocarcinoma of prostate PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs11540652 in TP53 gene and Brain Neoplasms PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs11540652 in TP53 gene and Brain Stem Glioma PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs11540652 in TP53 gene and Chronic Lymphocytic Leukemia PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs11540652 in TP53 gene and Colorectal Neoplasms PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs11540652 in TP53 gene and Cutaneous Melanoma PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs11540652 in TP53 gene and Esophageal carcinoma PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs11540652 in TP53 gene and Gastric Adenocarcinoma PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs11540652 in TP53 gene and Glioblastoma PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs11540652 in TP53 gene and LI-FRAUMENI SYNDROME 1 PMID 18511570 2008 Molecular basis of the Li-Fraumeni syndrome: an update from the French LFS families.

PMID 11139324 2001 Germline TP53 alterations in Finnish breast cancer families are rare and occur at conserved mutation-prone sites.

PMID 9242456 1997 Germ-line mutations of TP53 in Li-Fraumeni families: an extended study of 39 families.

PMID 19556618 2009 High frequency of de novo mutations in Li-Fraumeni syndrome.

PMID 21343334 2011 Dominant-negative features of mutant TP53 in germline carriers have limited impact on cancer outcomes.

PMID 17606709 2007 Transcriptional functionality of germ line p53 mutants influences cancer phenotype.

PMID 1565143 1992 Prevalence and spectrum of germline mutations of the p53 gene among patients with sarcoma.

PMID 21305319 2011 Joint effects of germ-line TP53 mutation, MDM2 SNP309, and gender on cancer risk in family studies of Li-Fraumeni syndrome.

PMID 21601526 2011 Biochemical and imaging surveillance in germline TP53 mutation carriers with Li-Fraumeni syndrome: a prospective observational study.

PMID 12826609 2003 Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis.

PMID 23161690 2013 The TP53 website: an integrative resource centre for the TP53 mutation database and TP53 mutant analysis.

PMID 21552135 2011 Gastric cancer in individuals with Li-Fraumeni syndrome.

rs11540652 in TP53 gene and Leukemia, Myelocytic, Acute PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

PMID 24641375 2014 Prognostic significance of TP53 mutations and single nucleotide polymorphisms in acute myeloid leukemia: a case series and literature review.

PMID 24381225 2014 Haploinsufficiency of del(5q) genes, Egr1 and Apc, cooperate with Tp53 loss to induce acute myeloid leukemia in mice.

PMID 24487413 2014 Comprehensive analysis of genetic alterations and their prognostic impacts in adult acute myeloid leukemia patients.

rs11540652 in TP53 gene and Li-Fraumeni Syndrome PMID 17606709 2007 Transcriptional functionality of germ line p53 mutants influences cancer phenotype.

PMID 20128691 2010 Analysis of the DNA-binding activity of p53 mutants using functional protein microarrays and its relationship to transcriptional activation.

PMID 2046748 1991 The p53 tumour suppressor gene.

PMID 15381368 2004 Identification of novel TP53 mutations in familial and sporadic cancer cases of German and Swiss origin.

PMID 25584008 2015 Prevalence and functional consequence of TP53 mutations in pediatric adrenocortical carcinoma: a children's oncology group study.

PMID 21601526 2011 Biochemical and imaging surveillance in germline TP53 mutation carriers with Li-Fraumeni syndrome: a prospective observational study.

PMID 1359493 1992 p53 mosaicism with an exon 8 germline mutation in the founder of a cancer-prone pedigree.

PMID 9242456 1997 Germ-line mutations of TP53 in Li-Fraumeni families: an extended study of 39 families.

PMID 17392385 2007 American Cancer Society guidelines for breast screening with MRI as an adjunct to mammography.

PMID 1565143 1992 Prevalence and spectrum of germline mutations of the p53 gene among patients with sarcoma.

PMID 21343334 2011 Dominant-negative features of mutant TP53 in germline carriers have limited impact on cancer outcomes.

PMID 7887414 1995 Germ-line p53 mutations in 15 families with Li-Fraumeni syndrome.

PMID 21305319 2011 Joint effects of germ-line TP53 mutation, MDM2 SNP309, and gender on cancer risk in family studies of Li-Fraumeni syndrome.

PMID 23538418 2013 Two hot spot mutant p53 mouse models display differential gain of function in tumorigenesis.

PMID 24493721 2014 American Society of Clinical Oncology Expert Statement: collection and use of a cancer family history for oncology providers.

rs11540652 in TP53 gene and Liver carcinoma PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

PMID 15004724 2004 Mutant p53 expression enhances drug resistance in a hepatocellular carcinoma cell line.

PMID 25157968 2014 Prospective enterprise-level molecular genotyping of a cohort of cancer patients.

rs11540652 in TP53 gene and MYELODYSPLASTIC SYNDROME PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs11540652 in TP53 gene and Malignant Uterine Corpus Neoplasm PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs11540652 in TP53 gene and Mammary Neoplasms PMID 16489069 2006 The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer.

PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

PMID 9569050 1998 Mutations in residues of TP53 that directly contact DNA predict poor outcome in human primary breast cancer.

rs11540652 in TP53 gene and Medulloblastoma PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs11540652 in TP53 gene and Multiple Myeloma PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs11540652 in TP53 gene and Neoplasms PMID 25157968 2014 Prospective enterprise-level molecular genotyping of a cohort of cancer patients.

PMID 24651012 2014 Mutant p53 in cancer: new functions and therapeutic opportunities.

rs11540652 in TP53 gene and Neoplastic Syndromes, Hereditary PMID 11793474 2002 Integrating mutation data and structural analysis of the TP53 tumor-suppressor protein.

PMID 20407015 2010 Altered-function p53 missense mutations identified in breast cancers can have subtle effects on transactivation.

PMID 11715068 2001 The timing and characterization of p53 mutations in progression from atypical ductal hyperplasia to invasive lesions in the breast cancer.

PMID 27683180 2017 Somatic and Germline TP53 Alterations in Second Malignant Neoplasms from Pediatric Cancer Survivors.

PMID 16760300 2006 Novel P53 mutations detected by FAMA in colorectal cancers.

PMID 26822237 2016 Diagnostic Yield of Clinical Tumor and Germline Whole-Exome Sequencing for Children With Solid Tumors.

PMID 16861262 2007 Inactive full-length p53 mutants lacking dominant wild-type p53 inhibition highlight loss of heterozygosity as an important aspect of p53 status in human cancers.

rs11540652 in TP53 gene and Serous cystadenocarcinoma ovary PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs11540652 in TP53 gene and Small cell carcinoma of lung PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs11540652 in TP53 gene and Squamous cell carcinoma of lung PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs11540652 in TP53 gene and Squamous cell carcinoma of skin PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs11540652 in TP53 gene and Squamous cell carcinoma of the head and neck PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs11540652 in TP53 gene and Transitional cell carcinoma of bladder PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs11540652 in TP53 gene and Uterine Carcinosarcoma PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.