Variant: rs121913315 

    present in Gene: STK11
    present in Chromosome: 19
    Position on Chromosome: 1220488
    Alleles of this Variant: G/A;T

rs121913315 in STK11 gene and Adenocarcinoma of lung (disorder) PMID 17676035 2007 LKB1 modulates lung cancer differentiation and metastasis.

rs121913315 in STK11 gene and Neoplasms PMID 25157968 2014 Prospective enterprise-level molecular genotyping of a cohort of cancer patients.

rs121913315 in STK11 gene and Neoplastic Syndromes, Hereditary PMID 17026623 2006 An updated mutation spectrum in an Australian series of PJS patients provides further evidence for only one gene locus.

PMID 15863673 2005 STK11 genotyping and cancer risk in Peutz-Jeghers syndrome.

PMID 23718779 2013 High Resolution Melting analysis as a rapid and efficient method of screening for small mutations in the STK11 gene in patients with Peutz-Jeghers syndrome.

PMID 10408777 1999 Novel mutations in the LKB1/STK11 gene in Dutch Peutz-Jeghers families.

PMID 12865922 2003 Further observations on LKB1/STK11 status and cancer risk in Peutz-Jeghers syndrome.

PMID 16582077 2006 Exonic STK11 deletions are not a rare cause of Peutz-Jeghers syndrome.

PMID 23399955 2013 Prevalence of germline PTEN, BMPR1A, SMAD4, STK11, and ENG mutations in patients with moderate-load colorectal polyps.

rs121913315 in STK11 gene and Peutz-Jeghers Syndrome PMID 9837816 1998 Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneity.

PMID 23718779 2013 High Resolution Melting analysis as a rapid and efficient method of screening for small mutations in the STK11 gene in patients with Peutz-Jeghers syndrome.

PMID 14976552 2004 LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.

PMID 12372054 2002 Mutation analysis of the STK11/LKB1 gene and clinical characteristics of an Australian series of Peutz-Jeghers syndrome patients.

PMID 17026623 2006 An updated mutation spectrum in an Australian series of PJS patients provides further evidence for only one gene locus.

PMID 9425897 1998 Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase.

PMID 9760200 1998 Nine novel germline mutations of STK11 in ten families with Peutz-Jeghers syndrome.

PMID 9428765 1998 A serine/threonine kinase gene defective in Peutz-Jeghers syndrome.

PMID 23240097 2013 Pancreatic cancer risk in Peutz-Jeghers syndrome patients: a large cohort study and implications for surveillance.

PMID 10408777 1999 Novel mutations in the LKB1/STK11 gene in Dutch Peutz-Jeghers families.

PMID 15987703 2005 LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes.

PMID 14517248 2003 MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm.

PMID 25226294 2014 Use of aromatase inhibitors in large cell calcifying sertoli cell tumors: effects on gynecomastia, growth velocity, and bone age.

PMID 19892943 2009 Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation.

PMID 16582077 2006 Exonic STK11 deletions are not a rare cause of Peutz-Jeghers syndrome.

PMID 12865922 2003 Further observations on LKB1/STK11 status and cancer risk in Peutz-Jeghers syndrome.

PMID 23399955 2013 Prevalence of germline PTEN, BMPR1A, SMAD4, STK11, and ENG mutations in patients with moderate-load colorectal polyps.

PMID 16287113 2005 High proportion of large genomic STK11 deletions in Peutz-Jeghers syndrome.

PMID 21411391 2011 A novel de novo mutation in LKB1 gene in a Chinese Peutz Jeghers syndrome patient significantly diminished p53 activity.

PMID 20435009 2010 Alu-mediated genomic deletion of the serine/threonine protein kinase 11 (STK11) gene in Peutz-Jeghers syndrome.

PMID 21189378 2011 mTOR inhibitor treatment of pancreatic cancer in a patient With Peutz-Jeghers syndrome.

rs121913315 in STK11 gene and melanoma PMID 10208439 1999 Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/STK11, in malignant melanoma.