present in Gene: GCKR
present in Chromosome: 2
Position on Chromosome: 27519736
Alleles of this Variant: T/C
rs780093 in
GCKR gene and
Arthritis, Gouty
PMID 20884846 2010 Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors.
PMID 23263486 2013 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
PMID 21768215 2011 Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function allele.
rs780093 in
GCKR gene and
Blood Pressure
PMID 21386085 2011 A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium.
rs780093 in
GCKR gene and
C-reactive protein measurement
PMID 23505291 2013 Gene-centric analysis identifies variants associated with interleukin-6 levels and shared pathways with other inflammation markers.
rs780093 in
GCKR gene and
Cardiovascular Diseases
PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
rs780093 in
GCKR gene and
Creatinine measurement, serum (procedure)
PMID 28452372 2017 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function.
rs780093 in
GCKR gene and
Crohn Disease
PMID 21102463 2010 Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
rs780093 in
GCKR gene and
Diabetes
PMID 31511532 2019 Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria.
rs780093 in
GCKR gene and
Diabetes Mellitus
PMID 31511532 2019 Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria.
rs780093 in
GCKR gene and
Estradiol level result
PMID 22829776 2012 A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.
rs780093 in
GCKR gene and
Estradiol measurement
PMID 22829776 2012 A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.
rs780093 in
GCKR gene and
Fatty acid measurement
PMID 23362303 2013 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.
rs780093 in
GCKR gene and
Glomerular Filtration Rate
PMID 31152163 2019 A catalog of genetic loci associated with kidney function from analyses of a million individuals.
PMID 31015462 2019 Sex-specific and pleiotropic effects underlying kidney function identified from GWAS meta-analysis.
PMID 28452372 2017 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function.
rs780093 in
GCKR gene and
Gout
PMID 23263486 2013 Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
PMID 21768215 2011 Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function allele.
PMID 29507422 2018 A large electronic-health-record-based genome-wide study of serum lipids.
rs780093 in
GCKR gene and
Metabolic Syndrome X
PMID 21386085 2011 A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium.
rs780093 in
GCKR gene and
Phospholipid measurement
PMID 23362303 2013 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.
PMID 29507422 2018 A large electronic-health-record-based genome-wide study of serum lipids.
PMID 28334899 2017 Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels.
PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
rs780093 in
GCKR gene and
Sex hormone binding globulin measurement
PMID 22829776 2012 Loci near the identified SNPs included SHBG (rs12150660, 17p13.1, p = 1.8 × 10(-106)), PRMT6 (rs17496332, 1p13.3, p = 1.4 × 10(-11)), GCKR (rs780093, 2p23.3, p = 2.2 × 10(-16)), ZBTB10 (rs440837, 8q21.13, p = 3.4 × 10(-09)), JMJD1C (rs7910927, 10q21.3, p = 6.1 × 10(-35)), SLCO1B1 (rs4149056, 12p12.1, p = 1.9 × 10(-08)), NR2F2 (rs8023580, 15q26.2, p = 8.3 × 10(-12)), ZNF652 (rs2411984, 17q21.32, p = 3.5 × 10(-14)), TDGF3 (rs1573036, Xq22.3, p = 4.1 × 10(-14)), LHCGR (rs10454142, 2p16.3, p = 1.3 × 10(-07)), BAIAP2L1 (rs3779195, 7q21.3, p = 2.7 × 10(-08)), and UGT2B15 (rs293428, 4q13.2, p = 5.5 × 10(-06)).
rs780093 in
GCKR gene and
Triglycerides measurement
PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
PMID 26780889 2016 Meta-analysis of lipid-traits in Hispanics identifies novel loci, population-specific effects, and tissue-specific enrichment of eQTLs.
PMID 26160806 2015 Contribution of Rare and Common Genetic Variants to Plasma Lipid Levels and Carotid Stiffness and Geometry: A Substudy of the Paris Prospective Study 3.
PMID 21386085 2011 A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium.
PMID 29507422 2018 A large electronic-health-record-based genome-wide study of serum lipids.
PMID 31217584 2019 Genetic analyses of diverse populations improves discovery for complex traits.
rs780093 in
GCKR gene and
Uric acid measurement (procedure)
PMID 20884846 2010 Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors.
PMID 19503597 2009 Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations.