Gene: GABRG3

Alternate names for this Gene: -

Gene Summary: This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. The protein encoded by this gene is a gamma subunit, which contains the benzodiazepine binding site. Two transcript variants encoding distinct isoforms have been found for this gene.

Gene is located in Chromosome: 15

Location in Chromosome : 15q12

Description of this Gene: gamma-aminobutyric acid type A receptor subunit gamma3

Type of Gene: protein-coding

rs74006954 in GABRG3 gene and Alzheimer's Disease PMID 23535033 2014 Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.

rs6606859 in GABRG3 gene and Calcification of coronary artery PMID 29221444 2017 Genome-wide association study of coronary artery calcified atherosclerotic plaque in African Americans with type 2 diabetes.

rs6497269 in GABRG3 gene and Color of iris PMID 18252221 2008 Three genome-wide association studies and a linkage analysis identify HERC2 as a human iris color gene.

rs6606859 in GABRG3 gene and Diabetes Mellitus, Non-Insulin-Dependent PMID 29221444 2017 Genome-wide association study of coronary artery calcified atherosclerotic plaque in African Americans with type 2 diabetes.

rs1432133 in GABRG3 gene and Hepatitis PMID 25705159 2014 Genome-wide association study of hepatitis in korean populations.

rs7497939 in GABRG3 gene and Hepatitis B PMID 24162738 2013 New loci associated with chronic hepatitis B virus infection in Han Chinese.

rs3101640 in GABRG3 gene and Narcolepsy PMID 19629137 2009 Genome-wide association database developed in the Japanese Integrated Database Project.

rs116046250 in GABRG3 gene and Ovarian Serous Adenocarcinoma PMID 31469419 2019 Identification of novel epithelial ovarian cancer loci in women of African ancestry.

rs192744896 in GABRG3 gene and Prostate carcinoma PMID 31095341 2020 Radiogenomics Consortium Genome-Wide Association Study Meta-Analysis of Late Toxicity After Prostate Cancer Radiotherapy.

rs34078361 in GABRG3 gene and mathematical ability PMID 30038396 2018 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.