Gene: VSNL1

Alternate names for this Gene: HLP3|HPCAL3|HUVISL1|VILIP|VILIP-1

Gene Summary: This gene is a member of the visinin/recoverin subfamily of neuronal calcium sensor proteins. The encoded protein is strongly expressed in granule cells of the cerebellum where it associates with membranes in a calcium-dependent manner and modulates intracellular signaling pathways of the central nervous system by directly or indirectly regulating the activity of adenylyl cyclase. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined.

Gene is located in Chromosome: 2

Location in Chromosome : 2p24.2

Description of this Gene: visinin like 1

Type of Gene: protein-coding

rs4038131 in VSNL1 gene and Acute transient psychotic disorder PMID 22005930 2012 Genome-wide association study of Alzheimer's disease with psychotic symptoms.

rs1033301 in VSNL1 gene and Alzheimer's Disease PMID 22005930 2012 Genome-wide association study of Alzheimer's disease with psychotic symptoms.

PMID 22005930 2012 SNPs upstream of SLC2A9 (rs6834555, P=3.0 × 10(-7)) and within VSNL1 (rs4038131, P=5.9 × 10(-7)) showed strongest evidence for association with AD+P when compared with controls.

rs2680830 in VSNL1 gene and Calcification of coronary artery PMID 29221444 2017 Genome-wide association study of coronary artery calcified atherosclerotic plaque in African Americans with type 2 diabetes.

rs2680830 in VSNL1 gene and Diabetes Mellitus, Non-Insulin-Dependent PMID 29221444 2017 Genome-wide association study of coronary artery calcified atherosclerotic plaque in African Americans with type 2 diabetes.

rs2710691 in VSNL1 gene and mathematical ability PMID 30038396 2018 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.