Variant: rs121913355 

    present in Gene: BRAF
    present in Chromosome: 7
    Position on Chromosome: 140781602
    Alleles of this Variant: C/A;G;T

rs121913355 in BRAF gene and Adenocarcinoma of lung (disorder) PMID 25157968 2014 Prospective enterprise-level molecular genotyping of a cohort of cancer patients.

PMID 22773810 2012 Lung cancers with acquired resistance to EGFR inhibitors occasionally harbor BRAF gene mutations but lack mutations in KRAS, NRAS, or MEK1.

PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs121913355 in BRAF gene and Adenocarcinoma of prostate PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs121913355 in BRAF gene and Carcinoma of lung PMID 19238210 2009 Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines.

PMID 12460918 2002 BRAF and RAS mutations in human lung cancer and melanoma.

PMID 22649091 2012 Kinase-impaired BRAF mutations in lung cancer confer sensitivity to dasatinib.

PMID 12460919 2002 Missense mutations of the BRAF gene in human lung adenocarcinoma.

PMID 19010912 2008 Genetic predictors of MEK dependence in non-small cell lung cancer.

PMID 12068308 2002 Mutations of the BRAF gene in human cancer.

PMID 23833300 2013 Clinical, pathologic, and biologic features associated with BRAF mutations in non-small cell lung cancer.

PMID 21483012 2011 Clinical characteristics of patients with lung adenocarcinomas harboring BRAF mutations.

rs121913355 in BRAF gene and Cardio-facio-cutaneous syndrome PMID 16474404 2006 Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome.

PMID 16439621 2006 Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome.

PMID 18042262 2008 Mutation and phenotypic spectrum in patients with cardio-facio-cutaneous and Costello syndrome.

PMID 19206169 2009 Germline BRAF mutations in Noonan, LEOPARD, and cardiofaciocutaneous syndromes: molecular diversity and associated phenotypic spectrum.

rs121913355 in BRAF gene and Colorectal Neoplasms PMID 20350999 2010 Prognostic and predictive biomarkers in resected colon cancer: current status and future perspectives for integrating genomics into biomarker discovery.

PMID 21129611 2010 Prognostic vs predictive molecular biomarkers in colorectal cancer: is KRAS and BRAF wild type status required for anti-EGFR therapy?

PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

PMID 19537845 2009 Clinical biomarkers in oncology: focus on colorectal cancer.

PMID 12068308 2002 Mutations of the BRAF gene in human cancer.

PMID 22310681 2012 The road to resistance: EGFR mutation and cetuximab.

PMID 18186519 2008 Rapid identification of somatic mutations in colorectal and breast cancer tissues using mismatch repair detection (MRD).

rs121913355 in BRAF gene and Cutaneous Melanoma PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs121913355 in BRAF gene and Lymphoma, Non-Hodgkin, Familial PMID 14612909 2003 BRAF mutations in non-Hodgkin's lymphoma.

rs121913355 in BRAF gene and Multiple Myeloma PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs121913355 in BRAF gene and Neoplasms PMID 15035987 2004 Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF.

PMID 25157968 2014 Prospective enterprise-level molecular genotyping of a cohort of cancer patients.

rs121913355 in BRAF gene and Non-Small Cell Lung Carcinoma PMID 12068308 2002 Mutations of the BRAF gene in human cancer.

rs121913355 in BRAF gene and Squamous cell carcinoma of lung PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs121913355 in BRAF gene and Squamous cell carcinoma of skin PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs121913355 in BRAF gene and Transitional cell carcinoma of bladder PMID 26619011 2016 Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.

rs121913355 in BRAF gene and melanoma PMID 18794803 2009 These G469E- and D594G-mutated melanomas were found to exhibit constitutive levels of phospho-extracellular signal-regulated kinase (pERK) and low levels of phospho-mitogen-activated protein kinase/ERK kinase (pMEK) and were resistant to MEK inhibition.

PMID 25157968 2014 Prospective enterprise-level molecular genotyping of a cohort of cancer patients.