Variant: rs671 

    present in Gene: ALDH2
    present in Chromosome: 12
    Position on Chromosome: 111803962
    Alleles of this Variant: G/A

rs671 in ALDH2 gene and Alcohol consumption PMID 28485404 2017 Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study.

PMID 23555315 2013 Genome-wide testing of putative functional exonic variants in relationship with breast and prostate cancer risk in a multiethnic population.

PMID 24277619 2014 When rs671 was considered as a candidate SNP in females, it explained 23.6% of the variation in flushing response, but alcohol consumption rates were too low among females-despite familial enrichment for AD-for an adequate test of association for either AD or maximum drinks.

rs671 in ALDH2 gene and Alcohol-Induced Disorders PMID 24277619 2014 "ALDH2 is associated to alcohol dependence and is the major genetic determinant of ""daily maximum drinks"" in a GWAS study of an isolated rural Chinese sample."

rs671 in ALDH2 gene and Alcohol-Related Disorders PMID 24277619 2014 "ALDH2 is associated to alcohol dependence and is the major genetic determinant of ""daily maximum drinks"" in a GWAS study of an isolated rural Chinese sample."

rs671 in ALDH2 gene and Alcoholic Intoxication, Chronic PMID 24277619 2014 When rs671 was considered as a candidate SNP in females, it explained 23.6% of the variation in flushing response, but alcohol consumption rates were too low among females-despite familial enrichment for AD-for an adequate test of association for either AD or maximum drinks.

rs671 in ALDH2 gene and Arthritis, Gouty PMID 31289104 2019 Genome-wide association study revealed novel loci which aggravate asymptomatic hyperuricaemia into gout.

rs671 in ALDH2 gene and Aspartate aminotransferase measurement PMID 30718733 2019 Moreover, 9 missense variants were newly identified, of which we identified new associations between a common population-specific missense variant, rs671 (p.Glu457Lys) of ALDH2, and two traits including aspartate aminotransferase (P = 5.20 × 10<sup>-13</sup>) and alanine aminotransferase (P = 4.98 × 10<sup>-8</sup>).

rs671 in ALDH2 gene and Body Height PMID 31562340 2019 Characterizing rare and low-frequency height-associated variants in the Japanese population.

rs671 in ALDH2 gene and Body mass index PMID 24861553 2014 The association of BMI with rs2237892, rs671 and rs12229654 was significantly stronger among men than among women.

rs671 in ALDH2 gene and Body mass index procedure PMID 24861553 2014 The association of BMI with rs2237892, rs671 and rs12229654 was significantly stronger among men than among women.

rs671 in ALDH2 gene and Coronary heart disease PMID 21971053 2012 Genome-wide association study of coronary artery disease in the Japanese.

rs671 in ALDH2 gene and Corpuscular Hemoglobin Concentration Mean PMID 28017375 2017 Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis.

PMID 20139978 2010 Genome-wide association study of hematological and biochemical traits in a Japanese population.

rs671 in ALDH2 gene and Drinking behavior processes PMID 23364009 2013 Moreover, we observed the association with drinking behavior for a functional variant in ALDH2 at 12q24 (rs671, P-discovery = 5.17 × 10(-35)).

PMID 21372407 2011 A cluster of 12 SNPs on 12q24 were found to significantly (P<5×10(-8)) associate with drinking behavior in stage 1, among which rs671 (a Glu-to-Lys substitution at position 504) in the ALDH2 gene showed the strongest association (odds ratio (OR)=0.16, P=3.6×10(-211) in the joint analysis).

rs671 in ALDH2 gene and Esophageal Neoplasms PMID 20833657 2010 Strong interaction between the effects of alcohol consumption and smoking on oesophageal squamous cell carcinoma among individuals with ADH1B and/or ALDH2 risk alleles.

PMID 19698717 2009 Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk.

rs671 in ALDH2 gene and Finding of Mean Corpuscular Hemoglobin PMID 28017375 2017 Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis.

rs671 in ALDH2 gene and Finding of body mass index PMID 24861553 2014 Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.

rs671 in ALDH2 gene and Gout PMID 31289104 2019 Genome-wide association study revealed novel loci which aggravate asymptomatic hyperuricaemia into gout.

rs671 in ALDH2 gene and Hemoglobin measurement PMID 20139978 2010 Genome-wide association study of hematological and biochemical traits in a Japanese population.

rs671 in ALDH2 gene and Hepatitis B PMID 21750111 2011 A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population.

rs671 in ALDH2 gene and Malignant neoplasm of esophagus PMID 19698717 2009 Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk.

PMID 21642993 2011 Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations.

rs671 in ALDH2 gene and Mean Corpuscular Volume (result) PMID 28017375 2017 Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis.

rs671 in ALDH2 gene and Metabolic Syndrome X PMID 28371326 2017 Notably, by an integrated analysis of the genotypes and the serum levels of APOA5, BUD13 and triglyceride, we observed that BUD13 was another potential mediator, besides APOA5, of the association between rs651821 and serum triglyceride. rs671 (ALDH2), an east Asian-specific common variant, was found to be associated with MetS (P<sub>combined</sub> = 9.7 × 10<sup>-22</sup> ) in Han Chinese.

rs671 in ALDH2 gene and Nasopharyngeal carcinoma PMID 20512145 2010 A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci.

rs671 in ALDH2 gene and Psoriasis PMID 25854761 2015 Whole-exome SNP array identifies 15 new susceptibility loci for psoriasis.

rs671 in ALDH2 gene and Serum gamma-glutamyl transferase measurement PMID 20139978 2010 Genome-wide association study of hematological and biochemical traits in a Japanese population.

rs671 in ALDH2 gene and Uric acid measurement (procedure) PMID 29124443 2018 Identification of CDC42BPG as a novel susceptibility locus for hyperuricemia in a Japanese population.

PMID 29408531 2018 The polymorphism rs671 at ALDH2 associated with serum uric acid levels in Chinese Han males: A genome-wide association study.

rs671 in ALDH2 gene and response to alcohol PMID 24277619 2014 "ALDH2 is associated to alcohol dependence and is the major genetic determinant of ""daily maximum drinks"" in a GWAS study of an isolated rural Chinese sample."