Gene: TCF7L2
Alternate names for this Gene: TCF-4|TCF4
Gene Summary: This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.
Gene is located in Chromosome: 10
Location in Chromosome : 10q25.2-q25.3
Description of this Gene: transcription factor 7 like 2
Type of Gene: protein-coding
rs11196170 in
TCF7L2 gene and
Adenocarcinoma of large intestine
PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.
PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.
PMID 29471430 2018 GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.
PMID 24836286 2014 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
PMID 30529582 2019 Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.
rs11196170 in
TCF7L2 gene and
Adenoma of large intestine
PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.
rs17747324 in
TCF7L2 gene and
Alzheimer's Disease
PMID 30805717 2019 Shared genetic architecture between metabolic traits and Alzheimer's disease: a large-scale genome-wide cross-trait analysis.
rs290481 in
TCF7L2 gene and
Ankle brachial pressure index (observable entity)
PMID 22361517 2012 In the European ancestry discovery meta-analyses, rs2171209 in SYTL3 (β=-0.007, p=6.02×10(-7)) and rs290481 in TCF7L2 (β=-0.008, p=7.01×10(-7)) were significantly associated with ABI.
rs4506565 in
TCF7L2 gene and
Atrial Fibrillation
PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
rs7903146 in
TCF7L2 gene and
Autoantibody measurement
PMID 19734900 2009 Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.
rs12772424 in
TCF7L2 gene and
Bipolar Disorder
PMID 24322204 2014 Genome-wide association study of bipolar disorder accounting for effect of body mass index identifies a new risk allele in TCF7L2.
rs7903146 in
TCF7L2 gene and
Birth Weight
PMID 31043758 2019 Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors.
rs11196169 in
TCF7L2 gene and
Body Height
PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
rs12243326 in
TCF7L2 gene and
Body mass index
PMID 22581228 2012 A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
PMID 24322204 2014 Genome-wide association study of bipolar disorder accounting for effect of body mass index identifies a new risk allele in TCF7L2.
PMID 26426971 2015 The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study.
PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
PMID 31453325 2019 Genotype-by-environment interactions inferred from genetic effects on phenotypic variability in the UK Biobank.
PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
PMID 30239722 2019 Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.
PMID 30108127 2018 A Large Multiethnic Genome-Wide Association Study of Adult Body Mass Index Identifies Novel Loci.
PMID 28892062 2017 Genome-wide association study identifies 112 new loci for body mass index in the Japanese population.
PMID 31217584 2019 Genetic analyses of diverse populations improves discovery for complex traits.
PMID 28448500 2017 Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.
PMID 28443625 2017 Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.
PMID 25673413 2015 Genetic studies of body mass index yield new insights for obesity biology.
rs10885405 in
TCF7L2 gene and
Breast Carcinoma
PMID 29059683 2017 Association analysis identifies 65 new breast cancer risk loci.
PMID 23544013 2013 Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk.
PMID 27117709 2016 Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer.
PMID 23535729 2013 Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
PMID 25751625 2015 Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.
rs11196170 in
TCF7L2 gene and
COLORECTAL CANCER, SUSCEPTIBILITY TO, 1
PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.
PMID 30529582 2019 Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.
PMID 24836286 2014 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
PMID 29471430 2018 GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.
PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.
rs11196170 in
TCF7L2 gene and
COLORECTAL CANCER, SUSCEPTIBILITY TO, 10
PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.
PMID 29471430 2018 GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.
PMID 30529582 2019 Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.
PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.
PMID 24836286 2014 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
rs11196170 in
TCF7L2 gene and
COLORECTAL CANCER, SUSCEPTIBILITY TO, 12
PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.
PMID 29471430 2018 GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.
PMID 30529582 2019 Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.
PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.
PMID 24836286 2014 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
rs11196170 in
TCF7L2 gene and
COLORECTAL CANCER, SUSCEPTIBILITY TO, 3
PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.
PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.
PMID 24836286 2014 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
PMID 29471430 2018 GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.
PMID 30529582 2019 Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.
rs4506565 in
TCF7L2 gene and
Cerebrovascular accident
PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
rs11196170 in
TCF7L2 gene and
Colorectal Carcinoma
PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.
PMID 30529582 2019 Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.
PMID 29471430 2018 GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.
PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.
PMID 24836286 2014 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
rs11196170 in
TCF7L2 gene and
Colorectal Neoplasms
PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.
PMID 30529582 2019 Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.
PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.
PMID 24836286 2014 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
PMID 29471430 2018 GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.
rs7901695 in
TCF7L2 gene and
Coronary Artery Disease
PMID 29212778 2018 Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease.
rs4506565 in
TCF7L2 gene and
Coronary heart disease
PMID 21347282 2011 Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
rs4506565 in
TCF7L2 gene and
Diabetes
PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
rs4506565 in
TCF7L2 gene and
Diabetes Mellitus
PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
rs10885409 in
TCF7L2 gene and
Diabetes Mellitus, Non-Insulin-Dependent
PMID 19184112 2009 Identification of susceptibility genes for complex diseases using pooling-based genome-wide association scans.
PMID 17293876 2007 A genome-wide association study identifies novel risk loci for type 2 diabetes.
PMID 20818381 2010 A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B.
PMID 30054458 2018 Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes.
PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
PMID 17463248 2007 A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.
PMID 17460697 2007 A variant in CDKAL1 influences insulin response and risk of type 2 diabetes.
PMID 17668382 2007 Type 2 diabetes whole-genome association study in four populations: the DiaGen consortium.
PMID 27189021 2016 Multi-ethnic genome-wide association study identifies novel locus for type 2 diabetes susceptibility.
PMID 29358691 2018 Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes.
PMID 25483131 2014 T2DM GWAS in the Lebanese population confirms the role of TCF7L2 and CDKAL1 in disease susceptibility.
PMID 26818947 2016 Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes.
PMID 31324766 2019 ZRANB3 is an African-specific type 2 diabetes locus associated with beta-cell mass and insulin response.
PMID 17463246 2007 Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.
PMID 21647700 2011 Genome-wide association and meta-analysis in populations from Starr County, Texas, and Mexico City identify type 2 diabetes susceptibility loci and enrichment for expression quantitative trait loci in top signals.
PMID 17554300 2007 Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
PMID 17463249 2007 Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.
PMID 30718926 2019 Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population.
PMID 21347282 2011 Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
PMID 23670970 2013 Genetic modifiers of cystic fibrosis-related diabetes.
PMID 19734900 2009 Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.
PMID 30470734 2018 Evidence for genetic contribution to the increased risk of type 2 diabetes in schizophrenia.
PMID 28254843 2017 Genetics of Type 2 Diabetes in U.S. Hispanic/Latino Individuals: Results From the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).
PMID 28869590 2017 Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.
PMID 19056611 2009 Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data.
PMID 19401414 2009 Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population.
PMID 20581827 2010 Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
PMID 21874001 2011 Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci.
PMID 22325160 2012 Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci.
PMID 24509480 2014 Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
PMID 31049640 2019 Fine-mapping of the TCF7L2 locus suggested one type 2 diabetes association signal shared between Europeans and Africans (indexed by rs7903146) and a distinct African-specific signal (indexed by rs17746147).
PMID 20694148 2010 A genome-wide association study of the metabolic syndrome in Indian Asian men.
PMID 24390345 2014 Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico.
PMID 22101970 2012 Subsequent GWAS using data from five institutions replicated the TCF7L2 gene variant (rs7903146) previously associated with T2D.
PMID 22693455 2012 Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.
PMID 22885922 2012 Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
PMID 23945395 2014 Genome-wide association study identifies three novel loci for type 2 diabetes.
PMID 26961502 2016 Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively.
PMID 23209189 2013 Genome-wide association study for type 2 diabetes in Indians identifies a new susceptibility locus at 2q21.
PMID 23300278 2013 Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India.
PMID 25102180 2014 Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes.
PMID 31118516 2019 Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls.
PMID 18372903 2008 Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.
rs4506565 in
TCF7L2 gene and
Diastolic blood pressure
PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
rs12243326 in
TCF7L2 gene and
Fasting blood glucose measurement
PMID 22581228 2012 A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
PMID 22885924 2012 Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.
PMID 30805717 2019 Shared genetic architecture between metabolic traits and Alzheimer's disease: a large-scale genome-wide cross-trait analysis.
PMID 31021400 2019 Pleiotropy informed adaptive association test of multiple traits using genome-wide association study summary data.
PMID 20081858 2010 New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
PMID 25631608 2015 Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility.
PMID 31217584 2019 Genetic analyses of diverse populations improves discovery for complex traits.
PMID 22885922 2012 Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
PMID 19060907 2009 Variants in MTNR1B influence fasting glucose levels.
rs12255372 in
TCF7L2 gene and
Fasting blood sugar result
PMID 22885924 2012 Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.
PMID 22885922 2012 Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
rs10885409 in
TCF7L2 gene and
Glucose measurement
PMID 29615537 2018 Strong impact of natural-selection-free heterogeneity in genetics of age-related phenotypes.
PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
PMID 27897004 2017 IDENTIFYING GENETIC ASSOCIATIONS WITH VARIABILITY IN METABOLIC HEALTH AND BLOOD COUNT LABORATORY VALUES: DIVING INTO THE QUANTITATIVE TRAITS BY LEVERAGING LONGITUDINAL DATA FROM AN EHR.
rs12243326 in
TCF7L2 gene and
Glucose tolerance test
PMID 20081857 2010 Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.
rs7903146 in
TCF7L2 gene and
Glycosuria
PMID 30476138 2019 Sequence variants associating with urinary biomarkers.
rs4506565 in
TCF7L2 gene and
Heart failure
PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
rs4506565 in
TCF7L2 gene and
Hematocrit procedure
PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
rs4506565 in
TCF7L2 gene and
High density lipoprotein measurement
PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
rs7903146 in
TCF7L2 gene and
Hip circumference
PMID 25673412 2015 New genetic loci link adipose and insulin biology to body fat distribution.
rs7903146 in
TCF7L2 gene and
Insulin measurement
PMID 21873549 2011 Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.
rs1006725 in
TCF7L2 gene and
Low density lipoprotein cholesterol measurement
PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
rs4506565 in
TCF7L2 gene and
Malignant Neoplasms
PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
rs7904519 in
TCF7L2 gene and
Malignant neoplasm of breast
PMID 23535729 2013 Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
rs11196170 in
TCF7L2 gene and
Malignant neoplasm of large intestine
PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.
PMID 30529582 2019 Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.
PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.
PMID 24836286 2014 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
PMID 29471430 2018 GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.
rs11196170 in
TCF7L2 gene and
Malignant tumor of colon
PMID 30510241 2019 Discovery of common and rare genetic risk variants for colorectal cancer.
PMID 24836286 2014 Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
PMID 26965516 2016 Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.
PMID 29471430 2018 GWAS identifies two novel colorectal cancer loci at 16q24.1 and 20q13.12.
PMID 30529582 2019 Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.
rs7903146 in
TCF7L2 gene and
Metabolic Syndrome X
PMID 20694148 2010 A genome-wide association study of the metabolic syndrome in Indian Asian men.
rs56299331 in
TCF7L2 gene and
Myopia
PMID 27182965 2016 Detection and interpretation of shared genetic influences on 42 human traits.
rs7903146 in
TCF7L2 gene and
Peripheral Arterial Diseases
PMID 31285632 2019 Genome-wide association study of peripheral artery disease in the Million Veteran Program.
rs7903146 in
TCF7L2 gene and
Physical Activity Measurement
PMID 28448500 2017 Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.
rs7094871 in
TCF7L2 gene and
Prostate carcinoma
PMID 29892016 2018 Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.
rs7903146 in
TCF7L2 gene and
Schizophrenia
PMID 30470734 2018 Evidence for genetic contribution to the increased risk of type 2 diabetes in schizophrenia.
rs1006725 in
TCF7L2 gene and
Serum LDL cholesterol measurement
PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
rs4506565 in
TCF7L2 gene and
Serum total cholesterol measurement
PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
rs7903146 in
TCF7L2 gene and
Smoking
PMID 28443625 2017 Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.
rs34872471 in
TCF7L2 gene and
Systolic Pressure
PMID 27841878 2017 Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation.
PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
PMID 30578418 2019 Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.
rs11594566 in
TCF7L2 gene and
Tonometry
PMID 29617998 2018 Genome-wide association analyses identify new loci influencing intraocular pressure.
PMID 29785010 2018 Genome-wide analyses identify 68 new loci associated with intraocular pressure and improve risk prediction for primary open-angle glaucoma.
rs3829191 in
TCF7L2 gene and
Triglycerides measurement
PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
rs35198068 in
TCF7L2 gene and
Uric acid measurement (procedure)
PMID 31578528 2019 Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels.
rs7903146 in
TCF7L2 gene and
Waist Circumference
PMID 25673412 2015 New genetic loci link adipose and insulin biology to body fat distribution.
rs6585201 in
TCF7L2 gene and
Waist-Hip Ratio
PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
rs10885409 in
TCF7L2 gene and
elevated blood glucose level
PMID 29615537 2018 Strong impact of natural-selection-free heterogeneity in genetics of age-related phenotypes.
PMID 27790247 2016 Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
PMID 27897004 2017 IDENTIFYING GENETIC ASSOCIATIONS WITH VARIABILITY IN METABOLIC HEALTH AND BLOOD COUNT LABORATORY VALUES: DIVING INTO THE QUANTITATIVE TRAITS BY LEVERAGING LONGITUDINAL DATA FROM AN EHR.
rs2104598 in
TCF7L2 gene and
mathematical ability
PMID 30038396 2018 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.